Q53ZU7 · Q53ZU7_MOUSE
- ProteinPeroxiredoxin-6
- GenePrdx6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids224 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 47 | Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | peroxiredoxin activity | |
Biological Process | lipid catabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxiredoxin-6
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ53ZU7
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Interaction
Subunit
Homodimer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. Interacts with APEX1. Interacts with STH. May interact with FAM168B. May interact with HTR2A.
Structure
Sequence
- Sequence statusComplete
- Length224
- Mass (Da)24,871
- Last updated2005-05-24 v1
- ChecksumAECDEDD332858B8F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY257203 EMBL· GenBank· DDBJ | AAP21829.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK168223 EMBL· GenBank· DDBJ | BAE40177.1 EMBL· GenBank· DDBJ | mRNA |