Q53ZU7 · Q53ZU7_MOUSE

  • Protein
    Peroxiredoxin-6
  • Gene
    Prdx6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site47Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionperoxiredoxin activity
Biological Processlipid catabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-6
  • EC number
  • Alternative names
    • 1-Cys peroxiredoxin
    • Acidic calcium-independent phospholipase A2
    • Glutathione-dependent peroxiredoxin
    • Lysophosphatidylcholine acyltransferase 5
    • Non-selenium glutathione peroxidase

Gene names

    • Name
      Prdx6

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 129/SvJ
    • DBA/2
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q53ZU7

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Interaction

Subunit

Homodimer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. Interacts with APEX1. Interacts with STH. May interact with FAM168B. May interact with HTR2A.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-169Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. Prx6 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    24,871
  • Last updated
    2005-05-24 v1
  • Checksum
    AECDEDD332858B8F
MPGGLLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNGETPTEKLPFPIIDDKGRDLAILLGMLDPVEKDDNNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTGTKPVATPVDWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYLRYTPQP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY257203
EMBL· GenBank· DDBJ
AAP21829.1
EMBL· GenBank· DDBJ
Genomic DNA
AK168223
EMBL· GenBank· DDBJ
BAE40177.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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