Significance of Gastrokine-1 Polymorphism Rs4254535 as a Prognostic Marker and its Association with Clinical Characteristics in Chinese Lung Cancer Patients.
AUF1 knockdown resulted in upregulation of GKN1 expression and promoted GKN1 mRNA decay by binding the 3' untranslated region of GKN1 mRNA H. pylori-induced AUF1 expression was associated with p-ERK activation and CagA.
The up-regulation of miR-544a could be crucially involved in the GKN1 translational repression thus suggesting its potential role as a biomarker and therapeutic target in gastric cancer patients.
GKN1 plays an important role in the maintenance of gastric homeostasis. In inflamed mucosa both with and without H. pylori infection GKN1 levels decrease while the protein is absent in gastric cancer. The measurement of circulating GKN1 concentration the protein itself or its mRNA in gastric tissue could be useful for the early diagnosis of cancer. (review)
The GKN1 is secreted and internalized in the gastric epithelium by exosome-driven transfer which inhibits gastric tumorigenesis and supports the clinical application of GKN1 protein in gastric cancer diagnosis and treatment.
Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1) and increased its ubiquitination to reduce the protein stability of GKN1.
Gastrokine 1 indirectly participates in actin stabilization since its overexpression in gastric cancer cells strongly increases the expression of tight and adherens junction proteins
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