Expression of PBX1 and MMD was higher in the second trimester among lupus patients who experienced a poor pregnancy outcome compared to those who did not. The pilot study identified two candidate genes that are reflective of the platelet function response to aspirin.
PBX1 is one of the determinants in the Cx32 promoter targeting site preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis.
results indicate that E2A-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them enhanced expression of ZNF521 may play a clinically relevant role in E2A fusion genes to develop B-lineage ALL
Review of the role of the E2A-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 as well as an enrichment of genes involved in immunity and infection pathways in ETV6-RUNX1 subtype
This association study successfully identified two susceptibility Single Nucleotide Polymorphisms (WNT9B and PBX1) associated with Mayer-Rokitansky-Kuster-Hauser syndrome risk both separately and interactively.
In this study we showed that TCF3-PBX1 positive pediatric BCP-ALL patients treated according to the JACLS ALL02 and CCLSG ALL2004 protocol had favorable outcomes
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13) may be a common genetic change in AIS and a survival determinant for female AIS patients at early stage.
Splice isoform PBX1-d is expressed more frequently in CD4+ T cells from lupus patients than from healthy controls. Its presence correlates with an increased central memory T cell population.
Identified 2 known single nucleotide polymorphisms which indicates that mutations in the coding sequence of PBX1 are not responsible for Mullerian duct abnormalities in Chinese women.
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