Q53JY8 · ACLA1_ORYSJ
- ProteinATP-citrate synthase subunit alpha chain protein 1
- GeneACLA-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids407 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. In contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains (By similarity).
Catalytic activity
- oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 327 | citrate (UniProtKB | ChEBI) | |||
Binding site | 329 | citrate (UniProtKB | ChEBI) | |||
Binding site | 360 | citrate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | ATP citrate synthase activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-citrate synthase subunit alpha chain protein 1
- EC number
- Short namesATP-citrate synthase A-1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ53JY8
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000412218 | 1-407 | UniProt | ATP-citrate synthase subunit alpha chain protein 1 | ||
Modified residue (large scale data) | 245 | PTMeXchange | Phosphoserine | |||
Proteomic databases
Interaction
Structure
Family & Domains
Sequence similarities
Belongs to the succinate/malate CoA ligase beta subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length407
- Mass (Da)45,005
- Last updated2011-09-21 v2
- MD5 Checksum687AB19BDFABF1C4C59A2B3DBC54CE1C
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0P0Y5P9 | A0A0P0Y5P9_ORYSJ | Os11g0693800 | 260 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC116367 EMBL· GenBank· DDBJ | AAX96579.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC146937 EMBL· GenBank· DDBJ | AAX95006.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
DP000010 EMBL· GenBank· DDBJ | ABA95455.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP008217 EMBL· GenBank· DDBJ | BAH95456.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP014967 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CM000148 EMBL· GenBank· DDBJ | EAZ19281.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |