Q53HM1 · Q53HM1_HUMAN
- ProteinUridine-cytidine kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids548 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- cytidine + ATP = CMP + ADP + H+
Pathway
Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | cytidine kinase activity | |
Molecular Function | uridine kinase activity | |
Biological Process | CTP salvage | |
Biological Process | phosphorylation | |
Biological Process | UMP salvage |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridine-cytidine kinase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ53HM1
Disease & Variants
Organism-specific databases
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-78 | Disordered | ||||
Sequence: MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPPVGTGRSPRKRTTSQCKSEPPLLRTSKRT | ||||||
Compositional bias | 25-43 | Basic and acidic residues | ||||
Sequence: GRQAEKSETACEDRSNAES | ||||||
Compositional bias | 56-71 | Polar residues | ||||
Sequence: SPRKRTTSQCKSEPPL | ||||||
Domain | 101-287 | Phosphoribulokinase/uridine kinase | ||||
Sequence: IGLGGGSASGKTTVARMIIEALDVPWVVLLSMDSFYKVLTEQQQEQAAHNNFNFDHPDAFDFDLIIFTLKKLKQGKSVKVPIYDFTTHSRKKDWKTLYGANVIIFEGIMAFADKTLLELLDMKIFVDTDSDIRLVRRLRRDISERGRDIEGVIKQYNKFVKPSFDQYIQPTMRLADIVVPRGSGNTV |
Sequence similarities
Belongs to the uridine kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length548
- Mass (Da)61,201
- Last updated2005-05-24 v1
- Checksum4DD744A1809D9120
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 25-43 | Basic and acidic residues | ||||
Sequence: GRQAEKSETACEDRSNAES | ||||||
Compositional bias | 56-71 | Polar residues | ||||
Sequence: SPRKRTTSQCKSEPPL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK222559 EMBL· GenBank· DDBJ | BAD96279.1 EMBL· GenBank· DDBJ | mRNA |