Our study unveils a mechanism of how TYMS is transcriptionally regulated by MYC and provides rationales for the precise use of TYMS inhibitors in the clinic.
Data suggest that assessing expression of thymidylate synthase and in conjunction with p21(WAF1)/p53 of colon cancers may improve the selection of patients suitable for 5-fluorouracil (5FU)-based adjuvant chemotherapy.
The thymidylate synthase genotype and XRCC1 Arg399Gln polymorphism might help to identify Stage II-III rectal cancer patients with a better outcome after preoperative concomitant chemoradiotherapy.
Observational study of gene-disease association gene-gene interaction gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Observed allelic frequencies in breast cnacer were: TSER (2) 0.54 and (3) 0.46; MTHFR C677T (C) 0.59 and (T) 0.41; p53 Arg72Pro (Arg) 0.73 and (Pro) 0.27; MDR1 C3435T (C) 0.52 and (T) 0.48; Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.