Data suggest that NDRG1 attenuates oncogenic signaling by inhibiting formation of EGFR/HER2 and HER2/HER3 heterodimers and by down-regulating EGFR via a mechanism involving its degradation. (NDRG1 = N-myc downstream regulated gene 1 protein; EGFR = epidermal growth factor receptor; HER = human epidermal growth factor receptor) (review)
NDRG1 prevented the degradation of c-Myc through Skp2-mediated ubiquitination in tumor cells. NDRG1 directly interacted with Skp2 and decreased phosphorylation of Skp2 through inactivation of CDK2.
Localization of N-myc downstream-regulated gene 1 and its significant correlation with p53 expression may play an important role in gastric cancer progression.
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