The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainFVB/NTissueLiverCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.Yanagimoto T., Itoh S., Sawada M., Kamataki T.View abstractCategoriesSequences, ExpressionSourceMGI: 88609PubMedEurope PMCArch Biochem Biophys 340:215-218 (1997)Mapped to3
Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol.Bornheim L.M., Everhart E.T., Li J., Correia M.A.View abstractCategoriesFunctionSourceMGI: 88609PubMedEurope PMCBiochem Pharmacol 48:161-171 (1994)Mapped to10
Multiple cytochrome P450 isozymes in murine skin: induction of P450 1A, 2B, 2E, and 3A by dexamethasone.Jugert F.K., Agarwal R., Kuhn A., Bickers D.R., Merk H.F., Mukhtar H.View abstractCategoriesSequences, ExpressionSourceMGI: 88609PubMedEurope PMCJ Invest Dermatol 102:970-975 (1994)Mapped to10
Genetic analysis of sensitization and tolerance to cocaine.Tolliver B.K., Belknap J.K., Woods W.E., Carney J.M.View abstractCategoriesSequences, Phenotypes & VariantsSourceMGI: 88609PubMedEurope PMCJ Pharmacol Exp Ther 270:1230-1238 (1994)Mapped to3
A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver.Itoh S., Satoh M., Abe Y., Hashimoto H., Yanagimoto T., Kamataki T.View abstractCategoriesSequencesSourceMGI: 88609PubMedEurope PMCEur. J. Biochem. 226:877-882 (1994)Cited in1Mapped to6
Chromosomal assignments of genes coding for components of the mixed- function oxidase system in mice. Genetic localization of the cytochrome P- 450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.Simmons D.L., Lalley P.A., Kasper C.B.View abstractCategoriesSequencesSourceMGI: 88609PubMedEurope PMCJ Biol Chem 260:515-521 (1985)Mapped to22
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoriesPTM / ProcessingSourceMGI: 88609PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.Uehara S., Iida Y., Ida-Tanaka M., Goto M., Kawai K., Yamamoto M., Higuchi Y., Ito S., Takahashi R.[...], Suemizu H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 88609PubMedEurope PMCSci Rep 12:14907-14907 (2022)Mapped to9
Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice.Lin Y., Wang S., Zhou Z., Guo L., Yu F., Wu B.View abstractCategoriesFunctionSourceMGI: 88609PubMedEurope PMCCommun Biol 2:378-378 (2019)Mapped to10
Mouse screen reveals multiple new genes underlying mouse and human hearing loss.Ingham N.J., Pearson S.A., Vancollie V.E., Rook V., Lewis M.A., Chen J., Buniello A., Martelletti E., Preite L.[...], Steel K.P.View abstractCategoriesSequencesSourceMGI: 88609PubMedEurope PMCPLoS Biol. 17:E3000194-E3000194 (2019)Cited in4Mapped to99+
Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.Long N., Tang H., Lin L., Li J., Guo L., Sun F., Dai M.View abstractCategoriesExpressionSourceMGI: 88609PubMedEurope PMCJ Toxicol Sci 44:299-307 (2019)Mapped to12
The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice.Tong Y., Zeng P., Zhang T., Zhao M., Yu P., Wu B.View abstractCategoriesFunction, ExpressionSourceMGI: 88609PubMedEurope PMCBiochem Pharmacol 163:215-224 (2019)Mapped to5
High fat diet induced obesity is mitigated in Cyp3a-null female mice.Kumar R., Litoff E.J., Boswell W.T., Baldwin W.S.View abstractSourceMGI: 88609PubMedEurope PMCChem Biol Interact 289:129-140 (2018)Mapped to3
Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice.Zurkinden L., Sviridov D., Vogt B., Escher G.View abstractCategoriesFunctionSourceMGI: 88609PubMedEurope PMCBiosci Rep 38:BSR20171162-BSR20171162 (2018)Mapped to30
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.Chen S., Lu W., Yueh M.F., Rettenmeier E., Liu M., Paszek M., Auwerx J., Yu R.T., Evans R.M.[...], Tukey R.H.View abstractCategoriesFunctionSourceMGI: 88609PubMedEurope PMCProc Natl Acad Sci U S A 114:E1432-E1440 (2017)Mapped to81
Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver Development.Ochiai W., Hirose A., Kawamura T., Komachi K., Yamamoto Y., Kitaoka S., Hatogai J., Kusunoki Y., Kon R.[...], Sugiyama K.View abstractCategoriesExpressionSourceMGI: 88609PubMedEurope PMCBiol Pharm Bull 39:2015-2021 (2016)Mapped to41
Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.Hashimoto M., Kobayashi K., Yamazaki M., Kazuki Y., Takehara S., Oshimura M., Chiba K.View abstractCategoriesFunctionSourceMGI: 88609PubMedEurope PMCJ Steroid Biochem Mol Biol 163:121-128 (2016)Mapped to14
Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.Liu X., Lu Y., Guan X., Dong B., Chavan H., Wang J., Zhang Y., Krishnamurthy P., Li F.View abstractCategoriesFunctionSourceMGI: 88609PubMedEurope PMCBiochem Pharmacol 97:111-121 (2015)Mapped to3
Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.Yanagida A., Chikada H., Ito K., Umino A., Kato-Itoh M., Yamazaki Y., Sato H., Kobayashi T., Yamaguchi T.[...], Kamiya A.View abstractCategoriesExpressionSourceMGI: 88609PubMedEurope PMCDev Biol 407:331-343 (2015)Mapped to29
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.Seth A., Ye J., Yu N., Guez F., Bedford D.C., Neale G.A., Cordi S., Brindle P.K., Lemaigre F.P.[...], Sosa-Pineda B.View abstractCategoriesFunction, ExpressionSourceMGI: 88609PubMedEurope PMCDevelopment 141:538-547 (2014)Mapped to99+
Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.Lee C., Ding X., Riddick D.S.View abstractCategoriesFunction, ExpressionSourceMGI: 88609PubMedEurope PMCDrug Metab Dispos 41:1782-1786 (2013)Mapped to9
Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.Hashimoto M., Kobayashi K., Watanabe M., Kazuki Y., Takehara S., Inaba A., Nitta S.I., Senda N., Oshimura M., Chiba K.View abstractCategoriesFunction, ExpressionSourceMGI: 88609PubMedEurope PMCJ Lipid Res 54:2060-2068 (2013)Mapped to5
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.Hendrikx J.J., Lagas J.S., Rosing H., Schellens J.H., Beijnen J.H., Schinkel A.H.View abstractCategoriesPTM / ProcessingSourceMGI: 88609PubMedEurope PMCInt J Cancer 132:2439-2447 (2013)Mapped to12
Impact of lactobacilli on orally acquired listeriosis.Archambaud C., Nahori M.A., Soubigou G., Becavin C., Laval L., Lechat P., Smokvina T., Langella P., Lecuit M., Cossart P.View abstractCategoriesFunction, ExpressionSourceMGI: 88609PubMedEurope PMCProc Natl Acad Sci U S A 109:16684-16689 (2012)Mapped to99+