Q52K88 · NUD13_ARATH

Function

function

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use diadenosine 5',5'''-P1P6 hexaphosphate (Ap6A), diadenosine 5',5'''-P1P5 pentaphosphate (Ap5A) and adenosine tetraphosphate (p4A) as substrates, but not diadenosine 5',5'''-P1P4 tetraphosphate (Ap4A), diadenosine 5',5'''-P1P3 triphosphate (Ap3A), deoxyribonucleoside triphosphates, ribonucleoside triphosphates, diphosphoinositol pentakisphosphate (PP-InsP5) and 5-phospho-alpha-D-ribosyl diphosphate (PRPP).

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Inhibited by fluoride.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.61 mMdiadenosine 5',5'''-P1P6 hexaphosphate
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
26.5 μmol/min/mgwith diadenosine 5',5'''-P1P6 hexaphosphate as substrate
Reducing conditions are required for the hydrolytic activity.

pH Dependence

Optimum pH is 8.5.

Temperature Dependence

Optimum temperature is 37 degrees Celsius.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site80Mg2+ (UniProtKB | ChEBI)
Binding site84Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionbis(5'-adenosyl)-pentaphosphatase activity
Molecular Functionhydrolase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nudix hydrolase 13, mitochondrial
  • EC number
  • Short names
    AtNUDT13

Gene names

    • Name
      NUDT13
    • Synonyms
      NUDX13
    • ORF names
      MLJ15.8
    • Ordered locus names
      At3g26690

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q52K88
  • Secondary accessions
    • Q29PY9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, transit peptide.

TypeIDPosition(s)Description
ChainPRO_0000019956?-202Nudix hydrolase 13, mitochondrial
Transit peptide1-?Mitochondrion

Proteomic databases

Expression

Tissue specificity

Expressed in roots, leaves, stems and inflorescences.

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain18-167Nudix hydrolase
Motif65-86Nudix box

Sequence similarities

Belongs to the Nudix hydrolase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    202
  • Mass (Da)
    23,187
  • Last updated
    2005-05-24 v1
  • Checksum
    C8B20342322B8297
MSNLSARTGRDHQRYDNNFRLVSGCIPYRLVKDEEEDSTSVDFENKLQVLMISSPNRHDLVFPKGGWEDDETVLEAASREAMEEAGVKGILREDPLGVWEFRSKSSSVEADCCLGGGCKGYMFALEVKEELAIWPEQDDRERRWLNVKEALELCRYEWMQSALEEFLRVMAEEGSTKEDSLAISSISNRGERQIDPRYCFVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB026648
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CP002686
EMBL· GenBank· DDBJ
AEE77199.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE77200.1
EMBL· GenBank· DDBJ
Genomic DNA
BT021980
EMBL· GenBank· DDBJ
AAY17417.1
EMBL· GenBank· DDBJ
mRNA
BT024767
EMBL· GenBank· DDBJ
ABD59105.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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