Q52EB3 · ATG1_PYRO7

Function

function

Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity).
Autophagy is essential to fungal development, production of appressorium turgor, and pathogenicity in rice blast disease (PubMed:17416896).

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site25-33ATP (UniProtKB | ChEBI)
Binding site48ATP (UniProtKB | ChEBI)
Active site162Proton acceptor

GO annotations

AspectTerm
Cellular ComponentAtg1/ULK1 kinase complex
Cellular Componentautophagosome membrane
Cellular Componentcytosol
Cellular Componentphagophore
Cellular Componentphagophore assembly site membrane
Cellular Componentvacuole-isolation membrane contact site
Molecular FunctionATP binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processappressorium formation
Biological Processautophagic cell death
Biological Processautophagosome assembly
Biological Processconidium germination
Biological Processpiecemeal microautophagy of the nucleus
Biological Processpositive regulation of conidium formation
Biological Processprotein transport
Biological Processregulation of autophagy
Biological Processreticulophagy
Biological Processspore germination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase ATG1
  • EC number
  • Alternative names
    • Autophagy-related protein 1

Gene names

    • Name
      ATG1
    • ORF names
      MGG_06393

Organism names

Accessions

  • Primary accession
    Q52EB3
  • Secondary accessions
    • G4N7K2
    • Q2Q439

Proteomes

Organism-specific databases

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000856481-982Serine/threonine-protein kinase ATG1

Expression

Tissue specificity

Uniformly detected in conidia, mycelia and appressoria (at protein level).

Interaction

Subunit

Homodimer. Forms a ternary complex with ATG13 and ATG17.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain19-324Protein kinase
Region334-506Disordered
Compositional bias336-356Basic and acidic residues
Compositional bias363-384Basic and acidic residues
Compositional bias393-407Polar residues
Compositional bias464-496Polar residues
Region813-834Disordered
Region898-918Disordered
Region947-982Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    982
  • Mass (Da)
    107,443
  • Last updated
    2005-06-07 v1
  • Checksum
    9811E0BC78307638
MADRSARRARPGDDSVGQFVIGAEIGKGSFAQVYMGKHKVSGAAVAIKSVELARLNKKLKENLYGEINILKTLRHPHIVALHDCVESATHINLMMEYCELGDLSLFIKKREKLSTNPATHDMARKYPNVPNSGLNEVVIRHFLKQLSSALKFLRESNLVHRDVKPQNLLLLPSPEFREVNKLARPILTASQDSLVPVAGLASLPMLKLADFGFARVLPSTSLAETLCGSPLYMAPEILRYERYDAKADLWSVGTVLFEMIVGRPPFRASNHVELLRKIEAAEDVIKFPRETTISSEMKGLTRALLKRNPVERISFENFFAHPVIISSIPGLVEDDIPKPEASEQRSSSKDTRAASKSDDPIASPRKYSFRRHPTDNDQIRDQFRRVEPPSSAAESAPSRQTSAFSGIAAEARKQAAAEASARTGQSSRNEPGDNLVPRRPQAQPSTSAPSKPGLYEERRRGISNASLNRSNRESSSPTSAALANDSARAPPQQTSRRVQAEEREKAAQDVAFERDYVVVEKKHVEVNAFADEMAANPRLGGQGTPLSPKSGQIVRRATQQGNPTSTTGAIPAAPSRTMQIAQGTQRHYHERGTSLSASPGSTASFITKAIQDASLRLLGIKYPAGLTKGASPPELYNPYPAYPTPSPPVGLISSGKQSTPVDEDARVAQLIEEHATRSDVVYGFAEVKYKQLVPLAPSAEHGLGGTTLEDMPTGEEDVLTVEAIVSLSEEALVLYVKALTLLAKSMDIASLWWARKNRGDQANNALSSTRDSVNTQTLSLRINSAVQWVRSRFNEVLEKAEVVRLRLMDAQKRLPDDHPSHPSNHPQGSESVNGASAEGVFLTVGVTAEKLMYDRALEMSRTAAINEITNEDLAGCEISYVTAIRMLEAVLDNDEDAPKRRLSANMDDSGGDGEDGHAEINADDQQAVQKMIHMIRSRLTSVRSKVRMISNASKAQQQSQPQSLIRRRSGDVTPRSVPSYSS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias336-356Basic and acidic residues
Compositional bias363-384Basic and acidic residues
Compositional bias393-407Polar residues
Compositional bias464-496Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ224381
EMBL· GenBank· DDBJ
ABB46201.1
EMBL· GenBank· DDBJ
mRNA
CM001234
EMBL· GenBank· DDBJ
EHA50859.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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