Q50960 · Q50960_NEIGO

  • Protein
    Probable peptidoglycan D,D-transpeptidase PenA
  • Gene
    penA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

158250100150200250300350400450500550
TypeIDPosition(s)Description
Active site310Acyl-ester intermediate

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processdivision septum assembly
Biological ProcessFtsZ-dependent cytokinesis
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable peptidoglycan D,D-transpeptidase PenA
  • EC number
  • Alternative names
    • Penicillin-binding protein 2
      (PBP-2
      )

Gene names

    • Name
      penA

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 3135
    • NG00029
    • NG00032
    • NG00049
    • NG00067
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    Q50960
  • Secondary accessions
    • Q51064

Subcellular Location

Cell inner membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane28-48Helical

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain71-220Penicillin-binding protein dimerisation
Domain263-558Penicillin-binding protein transpeptidase

Sequence similarities

Belongs to the transpeptidase family. FtsI subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    582
  • Mass (Da)
    63,765
  • Last updated
    1996-11-01 v1
  • Checksum
    241FBEF088160ECF
MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAMAVLFACLIARGLYLQTVTYNFLKEQGDNRIVRTQALPATRGTVSDRNGAVLALSAPTESLFAVPKDMKEMPSAAQLERLSELVDVPVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLYGEDGAEVVLRDRQGNIVDSLDSPRNKAPQNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPLSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHVATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB727732
EMBL· GenBank· DDBJ
BAM21191.1
EMBL· GenBank· DDBJ
Genomic DNA
AB727733
EMBL· GenBank· DDBJ
BAM21192.1
EMBL· GenBank· DDBJ
Genomic DNA
AB727742
EMBL· GenBank· DDBJ
BAM21201.1
EMBL· GenBank· DDBJ
Genomic DNA
AB727752
EMBL· GenBank· DDBJ
BAM21211.1
EMBL· GenBank· DDBJ
Genomic DNA
AB727758
EMBL· GenBank· DDBJ
BAM21217.1
EMBL· GenBank· DDBJ
Genomic DNA
AB727765
EMBL· GenBank· DDBJ
BAM21224.1
EMBL· GenBank· DDBJ
Genomic DNA
AB727766
EMBL· GenBank· DDBJ
BAM21225.1
EMBL· GenBank· DDBJ
Genomic DNA
X59632
EMBL· GenBank· DDBJ
CAA42191.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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