Q50746 · MOAA_METTM

Function

function

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15GTP (UniProtKB | ChEBI)
Binding site22[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site26[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site28S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site29[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site62GTP (UniProtKB | ChEBI)
Binding site66S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site92GTP (UniProtKB | ChEBI)
Binding site116S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site153GTP (UniProtKB | ChEBI)
Binding site249[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site252[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site254-256GTP (UniProtKB | ChEBI)
Binding site266[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncyclic pyranopterin monophosphate synthase activity
Molecular FunctionGTP 3',8'-cyclase activity
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological ProcessMo-molybdopterin cofactor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable GTP 3',8-cyclase
  • EC number
  • Alternative names
    • Molybdenum cofactor biosynthesis protein A

Gene names

    • Name
      moaA
    • Ordered locus names
      MTBMA_c01360

Organism names

Accessions

  • Primary accession
    Q50746
  • Secondary accessions
    • D9PU47

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001530211-305Probable GTP 3',8-cyclase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-228Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    34,831
  • Last updated
    2010-11-30 v2
  • Checksum
    36B65CED21C1D260
MQVHDNHRRPLVSLRISVTGRCNVSCIYCHRDGILRSDEEMSPEDIENICRVASDLGVKKIRLSGGEPLIRDDIVEIVEKINSIGFRDISITTNGTLLEDLSVPLRDAGLDRVNVSFDTLKPETYRFITRKDYLERVKAGIEGAVMAGLDPVKINMVILRGVNHHEIWDMFEFCRQQGAVLQIIELLKTDSCPDNGVERYHCDITPIEAELAEMADRIMTRKFMQDRKKYFIGDGEVEVVRPMDNTRFCANCTRLRVTPDGKLKPCLLRNDNLVDTKEALSSGDLEGLRELFLEAIRRRSPYYQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X87968
EMBL· GenBank· DDBJ
CAA61207.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001710
EMBL· GenBank· DDBJ
ADL57745.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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