Q503I2 · TRI13_DANRE

Function

function

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins (By similarity).

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for binding site.

140450100150200250300350400
TypeIDPosition(s)Description
Binding site92Zn2+ (UniProtKB | ChEBI)
Binding site95Zn2+ (UniProtKB | ChEBI)
Binding site115Zn2+ (UniProtKB | ChEBI)
Binding site121Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionligase activity
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processinnate immune response
Biological Processpositive regulation of type I interferon-mediated signaling pathway
Biological Processprotein monoubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tripartite motif-containing 13

Gene names

    • Name
      trim13
    • ORF names
      zgc:110578

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q503I2
  • Secondary accessions
    • F1R8C7

Proteomes

    • Identifier
    • Component
      Alternate scaffold 9, Chromosome 9

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Note: Also concentrates at the perinuclear endoplasmic reticulum.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane102-119Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004167651-404Tripartite motif-containing 13

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, coiled coil.

Type
IDPosition(s)Description
Zinc finger10-56RING-type
Zinc finger87-129B box-type
Coiled coil186-236

Domain

The C-terminal transmembrane domain is indispensable for the localization to the ER.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    404
  • Mass (Da)
    45,867
  • Last updated
    2005-06-07 v1
  • MD5 Checksum
    CD3D53A7A1F9C3D2F90A93DA491E304B
MELLEEDLTCPICCCLFEDPRVLPCSHSFCKKCLEGILDGNRSPTWRPPFKCPTCRKETVHNGIASLQVNYSLRGIVEKYNRIRVMPRMSQCRVHSGQPLNIFCATDLKLICGFCATTGDHKGHKFCALEEAYEREKLAFEELFRVVEGWKGAEVHSCLESLESAKKKALERVSRDADRVSEYFDKLLRTLEHKRSEILSDLETLKLAVMQTFDPEINRLRSALEEQRRALNIAESFRSLSDPLTFLQQMQDFREKLRVIQGTPLPSRTDMDVSLSALQSFDVKEWDRVRLGQVDKLCAPYESSAYLSSLPPAAAPRFTRVMWRVVLVVCACLPALNFLPSDCLALSFQDKVVALGGFSLPSPGEIVRWLGFCWKEAASICTLLTELCRNCMLDLINTTSDFIS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H9KUW1H9KUW1_DANREtrim13414

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU855930
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC095319
EMBL· GenBank· DDBJ
AAH95319.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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