Q502M5 · EDC3_DANRE

Function

function

Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentP-body
Molecular FunctionmRNA binding
Biological Processdeadenylation-independent decapping of nuclear-transcribed mRNA
Biological ProcessP-body assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enhancer of mRNA-decapping protein 3
  • Alternative names
    • LSM16 protein homolog
    • YjeF domain-containing protein 1

Gene names

    • Name
      edc3
    • Synonyms
      lsm16, yjdc
    • ORF names
      zgc:112006

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q502M5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, P-body
Note: Processing bodies (PB).

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001190591-507Enhancer of mRNA-decapping protein 3
Modified residue128Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-68Sm
Region1-77Required for P-body targeting and interaction with DCP1A
Compositional bias75-89Polar residues
Region75-113Disordered
Compositional bias154-173Polar residues
Region154-182Disordered
Region188-295Required for interaction with DDX6
Domain189-225DFDF
Region220-248Disordered
Domain282-486YjeF N-terminal

Domain

The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with other proteins (By similarity).

Sequence similarities

Belongs to the EDC3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    507
  • Mass (Da)
    54,852
  • Last updated
    2005-06-07 v1
  • Checksum
    7DFBE3D9D4E4BA9B
MALDWVGNLVSIHCGPTLGVYQGEISSVDQTSQTISLRNPFHNGVKCTVPEVTFSAMDIKDLKILEISKNSIEVSKQNGPESSSTTLMPHVGRKDKGGGGGGGGAPANSAPVMVPNKAEPRLQEGGVSPVPHYSKSYGERHIDMAVQGKGFRRRHNSWSSSCRGPNQATPKKNGLKNGGHMKNKDDECFGDGMDDVLDEDFDFEGNLALFDKAAVLSQIESSERRGNGARSRGTPGEQTPSRYRHDENILEAKPVVYRQITVPQNGSKEYSTDSGLVVPSISFELHKRLLAAAESHGLSLERRLEMTGVCASQMALTLLGGPNRLTPKNVHQRPTVALLCGPHVQGAQGISCGRHLANHEVEVVLFLPNFVKMLEAITSELALFGKTGGRLVSNVKDLPETPVDLVINCLDSHENGFLRDQPWYKAAADWANQNRAPVLSIDPPVSGQAHAVEAKWSLSLGLPLPLSEGAGRVYPCDIGIPRQVFQEVGIKYHSPFGCKFVIPLHSE

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1QL27F1QL27_DANREedc3506
A0A8M2BA31A0A8M2BA31_DANREedc3484
A0A8M2BAE2A0A8M2BAE2_DANREedc3486

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias75-89Polar residues
Compositional bias154-173Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC095641
EMBL· GenBank· DDBJ
AAH95641.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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