Q500V9 · DPB2_ARATH

Function

function

As accessory component of DNA polymerase II participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions (By similarity).
Is essential to promote the first divisions of the zygote (PubMed:16212602).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentepsilon DNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA polymerase binding
Biological ProcessDNA-templated DNA replication
Biological Processembryo development ending in seed dormancy
Biological Processpositive regulation of cell division

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase epsilon subunit B
  • Alternative names
    • DNA polymerase II subunit 2
      (AtDPB2
      )
    • Protein CYCLOPS 2

Gene names

    • Name
      DPB2
    • Synonyms
      CYL2
    • Ordered locus names
      At5g22110

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q500V9
  • Secondary accessions
    • Q56XM7
    • Q9C577

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Embryonic lethality when homozygous, due to embryo development arrested at one-cell stage.

Variants

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The viewer provides 46 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004367521-526DNA polymerase epsilon subunit B

Proteomic databases

Expression

Induction

Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase.

Developmental stage

During plant development, expressed in the shoot and root meristematic regions, but not inthe meristems in seeds at germination nor in trichomes undergoing endoreduplication. During male gametogenesis, transiently expressed in immature pollen grains at the time of post-meiotic mitosis, but not in the female macrospores at any time of development. Expressed in the embryo sac after fertilization and the in the embryo proper and suspensor cells until the globular stage. At the triangular stage, expressed in the forming shoot apical meristem.

Gene expression databases

Interaction

Subunit

Subunit of the DNA polymerase II (Probable). Interacts with POL2A (via C-terminus) (PubMed:16212602).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    526
  • Mass (Da)
    59,540
  • Last updated
    2005-06-07 v1
  • Checksum
    00E6A60B2EE777F4
MSSTSQKRKKIQKKFKNRGYNLKFDALDEILVFADQFPDDDDGEAIDLLLDNLQETHKSSTVDAESVRGLINRLLGAHNAPEEPTTSASSLAIIDAFLVPKFGYDSVKKKFNEHTSSLPIHGEASAKTALYRERFMLLSQRVSRAEHFSRPAFDAEMSQFENNEISSIQSLISQRGRKWVMGVISQLEDGHFYLEDLSASVEIDLSKAKITTGFFTENTIILAEGEMQVNGIFQVITCGFPPLEDRDKTLKAHSEYDFFGGGTLTKEEMIKLADLERQAVNDTFVILSDIWLDDEEVMRKLETVLDGFESVETVPSLFVFMGNFCSRPCNLSFGSYSSLREQFGKLGRMIGNHPRLKENSRFLFIPGPEDAGPSTVLPRCALPKYLTEELRNIIPNAIFSSNPCRVKFYNQEIVFFRQDLLYRMRRSCLVTPSSEETNDPFKHLVYTITHQSHLCPLPLMVQPIIWNYDHALRLYPTPHTIVLGDKSEQEVCKFGGTTCFNPGSFSTDSTFVAYRPSTQEVELSAL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8BH84A0A1P8BH84_ARATHDPB2495

Sequence caution

The sequence CAC34504.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict110in Ref. 3; BAD95306
Sequence conflict134in Ref. 3; BAD95306

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL589883
EMBL· GenBank· DDBJ
CAC34504.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED92984.1
EMBL· GenBank· DDBJ
Genomic DNA
AK221646
EMBL· GenBank· DDBJ
BAD95306.1
EMBL· GenBank· DDBJ
mRNA
BT022108
EMBL· GenBank· DDBJ
AAY34169.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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