Q500V9 · DPB2_ARATH
- ProteinDNA polymerase epsilon subunit B
- GeneDPB2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids526 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
As accessory component of DNA polymerase II participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions (By similarity).
Is essential to promote the first divisions of the zygote (PubMed:16212602).
Is essential to promote the first divisions of the zygote (PubMed:16212602).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | epsilon DNA polymerase complex | |
Molecular Function | DNA binding | |
Molecular Function | DNA polymerase binding | |
Biological Process | DNA-templated DNA replication | |
Biological Process | embryo development ending in seed dormancy | |
Biological Process | positive regulation of cell division |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase epsilon subunit B
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ500V9
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Embryonic lethality when homozygous, due to embryo development arrested at one-cell stage.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 46 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000436752 | 1-526 | DNA polymerase epsilon subunit B | |||
Sequence: MSSTSQKRKKIQKKFKNRGYNLKFDALDEILVFADQFPDDDDGEAIDLLLDNLQETHKSSTVDAESVRGLINRLLGAHNAPEEPTTSASSLAIIDAFLVPKFGYDSVKKKFNEHTSSLPIHGEASAKTALYRERFMLLSQRVSRAEHFSRPAFDAEMSQFENNEISSIQSLISQRGRKWVMGVISQLEDGHFYLEDLSASVEIDLSKAKITTGFFTENTIILAEGEMQVNGIFQVITCGFPPLEDRDKTLKAHSEYDFFGGGTLTKEEMIKLADLERQAVNDTFVILSDIWLDDEEVMRKLETVLDGFESVETVPSLFVFMGNFCSRPCNLSFGSYSSLREQFGKLGRMIGNHPRLKENSRFLFIPGPEDAGPSTVLPRCALPKYLTEELRNIIPNAIFSSNPCRVKFYNQEIVFFRQDLLYRMRRSCLVTPSSEETNDPFKHLVYTITHQSHLCPLPLMVQPIIWNYDHALRLYPTPHTIVLGDKSEQEVCKFGGTTCFNPGSFSTDSTFVAYRPSTQEVELSAL |
Proteomic databases
Expression
Induction
Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase.
Developmental stage
During plant development, expressed in the shoot and root meristematic regions, but not inthe meristems in seeds at germination nor in trichomes undergoing endoreduplication. During male gametogenesis, transiently expressed in immature pollen grains at the time of post-meiotic mitosis, but not in the female macrospores at any time of development. Expressed in the embryo sac after fertilization and the in the embryo proper and suspensor cells until the globular stage. At the triangular stage, expressed in the forming shoot apical meristem.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length526
- Mass (Da)59,540
- Last updated2005-06-07 v1
- Checksum00E6A60B2EE777F4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8BH84 | A0A1P8BH84_ARATH | DPB2 | 495 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 110 | in Ref. 3; BAD95306 | ||||
Sequence: K → R | ||||||
Sequence conflict | 134 | in Ref. 3; BAD95306 | ||||
Sequence: R → Q |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL589883 EMBL· GenBank· DDBJ | CAC34504.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED92984.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK221646 EMBL· GenBank· DDBJ | BAD95306.1 EMBL· GenBank· DDBJ | mRNA | ||
BT022108 EMBL· GenBank· DDBJ | AAY34169.1 EMBL· GenBank· DDBJ | mRNA |