Q500U8 · TKPR1_ARATH
- ProteinTetraketide alpha-pyrone reductase 1
- GeneTKPR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids326 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the biosynthesis of hydroxylated tetraketide compounds that serve as sporopollenin precursors (the main constituents of exine). Is essential for pollen wall development. Acts on tetraketide alpha-pyrones and reduces the carbonyl function on the tetraketide alkyl chain to a secondary alcohol function.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 8-32 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 44 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 162 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | nucleus | |
Molecular Function | oxidoreductase activity | |
Biological Process | pollen development | |
Biological Process | pollen exine formation | |
Biological Process | seed development | |
Biological Process | sporopollenin biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTetraketide alpha-pyrone reductase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ500U8
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: According to PubMed:21193572, TKPR1 is associated with the endoplasmic reticulum.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Male sterility due to distorted pollen grains lacking reticulate exine pattern.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000418214 | 1-326 | Tetraketide alpha-pyrone reductase 1 | ||
Proteomic databases
Expression
Tissue specificity
Specifically expressed in anther tapetal cells during microspores development.
Gene expression databases
Interaction
Subunit
Interacts with 4CLL1/ACOS5, PKSA and PKSB.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q500U8 | 4CLL1 Q9LQ12 | 3 | EBI-4432350, EBI-30859465 | |
BINARY | Q500U8 | PKSA O23674 | 2 | EBI-4432350, EBI-30859485 | |
BINARY | Q500U8 | PKSB Q8LDM2 | 2 | EBI-4432350, EBI-30859537 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)36,463
- Last updated2005-06-07 v1
- Checksum568FF7CC6D5C861E
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL022604 EMBL· GenBank· DDBJ | CAA18727.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161587 EMBL· GenBank· DDBJ | CAB80259.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE86509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT022119 EMBL· GenBank· DDBJ | AAY34180.1 EMBL· GenBank· DDBJ | mRNA | ||
BT025661 EMBL· GenBank· DDBJ | ABF74722.1 EMBL· GenBank· DDBJ | mRNA |