Q500U8 · TKPR1_ARATH

Function

function

Involved in the biosynthesis of hydroxylated tetraketide compounds that serve as sporopollenin precursors (the main constituents of exine). Is essential for pollen wall development. Acts on tetraketide alpha-pyrones and reduces the carbonyl function on the tetraketide alkyl chain to a secondary alcohol function.

Features

Showing features for binding site.

132650100150200250300
TypeIDPosition(s)Description
Binding site8-32NADP+ (UniProtKB | ChEBI)
Binding site44NADP+ (UniProtKB | ChEBI)
Binding site162NADP+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentnucleus
Molecular Functionoxidoreductase activity
Biological Processpollen development
Biological Processpollen exine formation
Biological Processseed development
Biological Processsporopollenin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tetraketide alpha-pyrone reductase 1
  • EC number
  • Alternative names
    • Protein DIHYDROFLAVONOL 4-REDUCTASE-LIKE 1

Gene names

    • Name
      TKPR1
    • Synonyms
      DRL1
    • ORF names
      F23E12.20
    • Ordered locus names
      At4g35420

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q500U8
  • Secondary accessions
    • O65487

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Endoplasmic reticulum
Note: According to PubMed:21193572, TKPR1 is associated with the endoplasmic reticulum.

Keywords

Phenotypes & Variants

Disruption phenotype

Male sterility due to distorted pollen grains lacking reticulate exine pattern.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004182141-326Tetraketide alpha-pyrone reductase 1

Proteomic databases

Expression

Tissue specificity

Specifically expressed in anther tapetal cells during microspores development.

Gene expression databases

Interaction

Subunit

Interacts with 4CLL1/ACOS5, PKSA and PKSB.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q500U84CLL1 Q9LQ123EBI-4432350, EBI-30859465
BINARY Q500U8PKSA O236742EBI-4432350, EBI-30859485
BINARY Q500U8PKSB Q8LDM22EBI-4432350, EBI-30859537

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    36,463
  • Last updated
    2005-06-07 v1
  • Checksum
    568FF7CC6D5C861E
MDQAKGKVCVTGASGFLASWLVKRLLLEGYEVIGTVRDPGNEKKLAHLWKLEGAKERLRLVKADLMEEGSFDNAIMGCQGVFHTASPVLKPTSNPEEEILRPAIEGTLNVLRSCRKNPSLKRVVLTSSSSTVRIRDDFDPKIPLDESIWTSVELCKRFQVWYALSKTLAEQAAWKFSEENGIDLVTVLPSFLVGPSLPPDLCSTASDVLGLLKGETEKFQWHGQMGYVHIDDVARTHIVVFEHEAAQGRYICSSNVISLEELVSFLSARYPSLPIPKRFEKLNRLHYDFDTSKIQSLGLKFKSLEEMFDDCIASLVEQGYLSTVLP

Sequence caution

The sequence CAA18727.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB80259.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL022604
EMBL· GenBank· DDBJ
CAA18727.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161587
EMBL· GenBank· DDBJ
CAB80259.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE86509.1
EMBL· GenBank· DDBJ
Genomic DNA
BT022119
EMBL· GenBank· DDBJ
AAY34180.1
EMBL· GenBank· DDBJ
mRNA
BT025661
EMBL· GenBank· DDBJ
ABF74722.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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