Q4ZHV6 · Q4ZHV6_MANSE
- ProteinBeta amyloid protein-like protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids804 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | neuron projection | |
Cellular Component | neuronal cell body | |
Molecular Function | heparin binding | |
Molecular Function | transition metal ion binding | |
Biological Process | axonogenesis | |
Biological Process | central nervous system development |
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Protostomia > Ecdysozoa > Panarthropoda > Arthropoda (arthropods) > Mandibulata > Pancrustacea > Hexapoda (insects) > Insecta (true insects) > Dicondylia > Pterygota (winged insects) > Neoptera > Endopterygota > Amphiesmenoptera > Lepidoptera (butterflies and moths) > Glossata > Neolepidoptera > Heteroneura > Ditrysia > Obtectomera > Bombycoidea (hawk-moths) > Sphingidae (hawkmoths) > Sphinginae (small-eyed sphinx moth) > Sphingini > Manduca
Accessions
- Primary accessionQ4ZHV6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 731-754 | Helical | ||||
Sequence: ALYPALCVGGAALAAAACVALAVA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MTRAVLFISVFTIFLDVLHA | ||||||
Chain | PRO_5004247556 | 21-804 | ||||
Sequence: GQASSGAEPQVAVLCEAGSTYHPQYMSAAGRWTPDLTTKPHNCLKDKMEILDYCKKVYPSHDITNIVEASHYVKVSNWCKLGTSNAAKCKVTRWVKPFRCLEGPFQSDALLVPESCLFDHIHNQSRCWQFARWNATAGRACAQRGLRLRTFAMLLPCGISLFSGVEFVCCPKHFKENVKMHKPMDVGVPVSPGGEDMLAASAAMDERDDDLLDDDDALDDDDDDDTLNLSDDDDDDDADDDMDEDEDADLSRDDDAEDDDYTDADDSAWPRPESSSSPSTTTSTTTTTTTTTASTATSDPYFSHFDPRTEHQSYKDAQQRLEETHREKITKVMKEWSELEDRYQAMMSADPAAAQTFRQRMTAKFQANVQSLEEEGVAERRRLAALHQQRVLAHLAQRRRTALACYTRSLRDTPPNAHRVQKCLQRLVRALAAERSGALAAWRRAAAAGREAAAAERTSAADRLQDADRALQRALTALRRRPHLYASIGTAIEDYVQSMQSKDDMAVSLMSMTPEAEELLLDRIEAEVQREQAAREQLSVKRDQRARQRQDIQNERAKTSNGVKESEESDDEASEPSENETSTAAPTPTSAPSSPASATPAPSAAPVSVHDITTRSGFTQDTTTTEMITTTVTDAPESETAETIEASETTSRRSTSETEGEGLRAALEHAEERAPPPPAHALKHELQHSQPGYTVRGAGPSGAGGAGGSGALYPALCVGGAALAAAACVALAVARRRDRAPHAQGFVQVEQTGVVAPTPEERHVANMQINGYENPTYKYFEVKE | ||||||
Disulfide bond | 136↔190 | |||||
Sequence: CLFDHIHNQSRCWQFARWNATAGRACAQRGLRLRTFAMLLPCGISLFSGVEFVCC | ||||||
Disulfide bond | 147↔177 | |||||
Sequence: CWQFARWNATAGRACAQRGLRLRTFAMLLPC | ||||||
Disulfide bond | 161↔189 | |||||
Sequence: CAQRGLRLRTFAMLLPCGISLFSGVEFVC |
Keywords
- PTM
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q4ZHV6 | P53359 | 5 | EBI-8838689, EBI-8838702 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-126 | GFLD subdomain | ||||
Sequence: SGAEPQVAVLCEAGSTYHPQYMSAAGRWTPDLTTKPHNCLKDKMEILDYCKKVYPSHDITNIVEASHYVKVSNWCKLGTSNAAKCKVTRWVKPFRCLEGPFQ | ||||||
Domain | 25-192 | E1 | ||||
Sequence: SGAEPQVAVLCEAGSTYHPQYMSAAGRWTPDLTTKPHNCLKDKMEILDYCKKVYPSHDITNIVEASHYVKVSNWCKLGTSNAAKCKVTRWVKPFRCLEGPFQSDALLVPESCLFDHIHNQSRCWQFARWNATAGRACAQRGLRLRTFAMLLPCGISLFSGVEFVCCPK | ||||||
Region | 134-192 | CuBD subdomain | ||||
Sequence: ESCLFDHIHNQSRCWQFARWNATAGRACAQRGLRLRTFAMLLPCGISLFSGVEFVCCPK | ||||||
Compositional bias | 230-284 | Acidic residues | ||||
Sequence: DLLDDDDALDDDDDDDTLNLSDDDDDDDADDDMDEDEDADLSRDDDAEDDDYTDA | ||||||
Region | 230-339 | Disordered | ||||
Sequence: DLLDDDDALDDDDDDDTLNLSDDDDDDDADDDMDEDEDADLSRDDDAEDDDYTDADDSAWPRPESSSSPSTTTSTTTTTTTTTASTATSDPYFSHFDPRTEHQSYKDAQQ | ||||||
Compositional bias | 289-322 | Polar residues | ||||
Sequence: WPRPESSSSPSTTTSTTTTTTTTTASTATSDPYF | ||||||
Domain | 317-515 | E2 | ||||
Sequence: TSDPYFSHFDPRTEHQSYKDAQQRLEETHREKITKVMKEWSELEDRYQAMMSADPAAAQTFRQRMTAKFQANVQSLEEEGVAERRRLAALHQQRVLAHLAQRRRTALACYTRSLRDTPPNAHRVQKCLQRLVRALAAERSGALAAWRRAAAAGREAAAAERTSAADRLQDADRALQRALTALRRRPHLYASIGTAIEDY | ||||||
Compositional bias | 324-339 | Basic and acidic residues | ||||
Sequence: HFDPRTEHQSYKDAQQ | ||||||
Compositional bias | 555-587 | Basic and acidic residues | ||||
Sequence: REQLSVKRDQRARQRQDIQNERAKTSNGVKESE | ||||||
Region | 555-684 | Disordered | ||||
Sequence: REQLSVKRDQRARQRQDIQNERAKTSNGVKESEESDDEASEPSENETSTAAPTPTSAPSSPASATPAPSAAPVSVHDITTRSGFTQDTTTTEMITTTVTDAPESETAETIEASETTSRRSTSETEGEGLR | ||||||
Compositional bias | 598-621 | Polar residues | ||||
Sequence: ENETSTAAPTPTSAPSSPASATPA | ||||||
Compositional bias | 629-671 | Polar residues | ||||
Sequence: VHDITTRSGFTQDTTTTEMITTTVTDAPESETAETIEASETTS |
Sequence similarities
Belongs to the APP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length804
- Mass (Da)88,203
- Last updated2011-07-27 v3
- ChecksumC7222A7D39F73E57
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 230-284 | Acidic residues | ||||
Sequence: DLLDDDDALDDDDDDDTLNLSDDDDDDDADDDMDEDEDADLSRDDDAEDDDYTDA | ||||||
Compositional bias | 289-322 | Polar residues | ||||
Sequence: WPRPESSSSPSTTTSTTTTTTTTTASTATSDPYF | ||||||
Compositional bias | 324-339 | Basic and acidic residues | ||||
Sequence: HFDPRTEHQSYKDAQQ | ||||||
Compositional bias | 555-587 | Basic and acidic residues | ||||
Sequence: REQLSVKRDQRARQRQDIQNERAKTSNGVKESE | ||||||
Compositional bias | 598-621 | Polar residues | ||||
Sequence: ENETSTAAPTPTSAPSSPASATPA | ||||||
Compositional bias | 629-671 | Polar residues | ||||
Sequence: VHDITTRSGFTQDTTTTEMITTTVTDAPESETAETIEASETTS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ008058 EMBL· GenBank· DDBJ | AAY25024.3 EMBL· GenBank· DDBJ | mRNA |