Q4ZHG4 · FNDC1_HUMAN

  • Protein
    Fibronectin type III domain-containing protein 1
  • Gene
    FNDC1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be an activator of G protein signaling.

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fibronectin type III domain-containing protein 1
  • Alternative names
    • Activation-associated cDNA protein
    • Expressed in synovial lining protein

Gene names

    • Name
      FNDC1
    • Synonyms
      FNDC2, KIAA1866, MEL4B3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4ZHG4
  • Secondary accessions
    • A6H8X2
    • B7ZBR4
    • B7ZBR5
    • B9EK49
    • Q5JPI0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_031826438in dbSNP:rs509648
Natural variantVAR_031827463in dbSNP:rs420137
Natural variantVAR_0318281003in dbSNP:rs370434
Natural variantVAR_0318291180in dbSNP:rs420054
Natural variantVAR_0318301261in dbSNP:rs3003174
Natural variantVAR_0318311280in dbSNP:rs2501176
Natural variantVAR_0632251479-1484in dbSNP:rs3842694
Natural variantVAR_0318321504in dbSNP:rs386360
Natural variantVAR_0318331574in dbSNP:rs7763726

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2,606 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
Signal1-32UniProt
ChainPRO_000028483133-1894UniProtFibronectin type III domain-containing protein 1
Glycosylation149UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)537PRIDEPhosphoserine
Modified residue (large scale data)548PRIDEPhosphoserine
Modified residue717UniProtPhosphoserine
Modified residue (large scale data)1083PRIDEPhosphoserine
Modified residue (large scale data)1176PRIDEPhosphoserine
Glycosylation1661UniProtN-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis.

Induction

By TGFB1 present in the melanoma cell conditioned medium (MCCM).

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain39-131Fibronectin type-III 1
Domain158-258Fibronectin type-III 2
Domain262-357Fibronectin type-III 3
Domain362-457Fibronectin type-III 4
Region455-500Disordered
Region515-1271Disordered
Compositional bias619-641Polar residues
Compositional bias669-683Polar residues
Compositional bias752-782Polar residues
Compositional bias784-800Basic and acidic residues
Compositional bias840-858Polar residues
Compositional bias861-887Basic and acidic residues
Compositional bias904-928Basic and acidic residues
Compositional bias932-971Polar residues
Compositional bias1000-1014Pro residues
Compositional bias1015-1074Polar residues
Compositional bias1239-1253Pro residues
Region1311-1350Disordered
Compositional bias1444-1505Polar residues
Region1444-1515Disordered
Domain1658-1752Fibronectin type-III 5

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q4ZHG4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,894
  • Mass (Da)
    205,558
  • Last updated
    2010-06-15 v4
  • Checksum
    7A0A9D0445E511D8
MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW

Q4ZHG4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 394-457: EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTT → A

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
J3KNQ2J3KNQ2_HUMANFNDC11790

Sequence caution

The sequence AAI46784.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAI50608.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAY26234.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAE51894.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict36in Ref. 1; AAY26234
Sequence conflict122in Ref. 4; AAI50608
Alternative sequenceVSP_024663394-457in isoform 2
Compositional bias619-641Polar residues
Compositional bias669-683Polar residues
Compositional bias752-782Polar residues
Compositional bias784-800Basic and acidic residues
Compositional bias840-858Polar residues
Compositional bias861-887Basic and acidic residues
Compositional bias904-928Basic and acidic residues
Compositional bias932-971Polar residues
Compositional bias1000-1014Pro residues
Compositional bias1015-1074Polar residues
Compositional bias1239-1253Pro residues
Sequence conflict1295in Ref. 6; CAE51894
Compositional bias1444-1505Polar residues
Sequence conflict1487in Ref. 6; CAE51894
Sequence conflict1685in Ref. 6; CAE51894
Sequence conflict1894in Ref. 6; CAE51894

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ009660
EMBL· GenBank· DDBJ
AAY26234.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL355492
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL356417
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL590551
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AB058769
EMBL· GenBank· DDBJ
BAB47495.2
EMBL· GenBank· DDBJ
mRNA
BC146783
EMBL· GenBank· DDBJ
AAI46784.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC150607
EMBL· GenBank· DDBJ
AAI50608.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL832410
EMBL· GenBank· DDBJ
CAI46178.2
EMBL· GenBank· DDBJ
mRNA
AJ586132
EMBL· GenBank· DDBJ
CAE51894.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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