Q4ZHG4 · FNDC1_HUMAN
- ProteinFibronectin type III domain-containing protein 1
- GeneFNDC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1894 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be an activator of G protein signaling.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibronectin type III domain-containing protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4ZHG4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_031826 | 438 | in dbSNP:rs509648 | |||
Sequence: T → A | ||||||
Natural variant | VAR_031827 | 463 | in dbSNP:rs420137 | |||
Sequence: E → Q | ||||||
Natural variant | VAR_031828 | 1003 | in dbSNP:rs370434 | |||
Sequence: Q → E | ||||||
Natural variant | VAR_031829 | 1180 | in dbSNP:rs420054 | |||
Sequence: D → E | ||||||
Natural variant | VAR_031830 | 1261 | in dbSNP:rs3003174 | |||
Sequence: L → P | ||||||
Natural variant | VAR_031831 | 1280 | in dbSNP:rs2501176 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_063225 | 1479-1484 | in dbSNP:rs3842694 | |||
Sequence: Missing | ||||||
Natural variant | VAR_031832 | 1504 | in dbSNP:rs386360 | |||
Sequence: T → K | ||||||
Natural variant | VAR_031833 | 1574 | in dbSNP:rs7763726 | |||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,606 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-32 | UniProt | |||||
Sequence: MAPEAGATLRAPRRLSWAALLLLAALLPVASS | |||||||
Chain | PRO_0000284831 | 33-1894 | UniProt | Fibronectin type III domain-containing protein 1 | |||
Sequence: AAASVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW | |||||||
Glycosylation | 149 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 537 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 548 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 717 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1083 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1176 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 1661 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis.
Induction
By TGFB1 present in the melanoma cell conditioned medium (MCCM).
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 39-131 | Fibronectin type-III 1 | ||||
Sequence: HPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVSRPVYRAESPPG | ||||||
Domain | 158-258 | Fibronectin type-III 2 | ||||
Sequence: PNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEED | ||||||
Domain | 262-357 | Fibronectin type-III 3 | ||||
Sequence: VPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPES | ||||||
Domain | 362-457 | Fibronectin type-III 4 | ||||
Sequence: APENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTT | ||||||
Region | 455-500 | Disordered | ||||
Sequence: PTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGR | ||||||
Region | 515-1271 | Disordered | ||||
Sequence: ANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSP | ||||||
Compositional bias | 619-641 | Polar residues | ||||
Sequence: SPAHHASTQGTSHRPSLPASLND | ||||||
Compositional bias | 669-683 | Polar residues | ||||
Sequence: ALSPSRQSPSSVLRD | ||||||
Compositional bias | 752-782 | Polar residues | ||||
Sequence: ATNSNAPSRSTMSSSVSSHLSSRTQVSEGAE | ||||||
Compositional bias | 784-800 | Basic and acidic residues | ||||
Sequence: SDGESHGDGDREDGGRQ | ||||||
Compositional bias | 840-858 | Polar residues | ||||
Sequence: GPRLQPSSSPQSTVPSRAH | ||||||
Compositional bias | 861-887 | Basic and acidic residues | ||||
Sequence: VPSHSDSHPKLSSGIHGDEEDEKPLPA | ||||||
Compositional bias | 904-928 | Basic and acidic residues | ||||
Sequence: RGWEDLRRSPQRGASLHRKEPIPEN | ||||||
Compositional bias | 932-971 | Polar residues | ||||
Sequence: TGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGS | ||||||
Compositional bias | 1000-1014 | Pro residues | ||||
Sequence: RAPQQQPPPPVATSQ | ||||||
Compositional bias | 1015-1074 | Polar residues | ||||
Sequence: HHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDED | ||||||
Compositional bias | 1239-1253 | Pro residues | ||||
Sequence: PVKRPLPPPPGSSPR | ||||||
Region | 1311-1350 | Disordered | ||||
Sequence: LSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIING | ||||||
Compositional bias | 1444-1505 | Polar residues | ||||
Sequence: THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTP | ||||||
Region | 1444-1515 | Disordered | ||||
Sequence: THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPG | ||||||
Domain | 1658-1752 | Fibronectin type-III 5 | ||||
Sequence: APRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q4ZHG4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,894
- Mass (Da)205,558
- Last updated2010-06-15 v4
- Checksum7A0A9D0445E511D8
Q4ZHG4-2
- Name2
- Differences from canonical
- 394-457: EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTT → A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
J3KNQ2 | J3KNQ2_HUMAN | FNDC1 | 1790 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 36 | in Ref. 1; AAY26234 | ||||
Sequence: S → P | ||||||
Sequence conflict | 122 | in Ref. 4; AAI50608 | ||||
Sequence: P → S | ||||||
Alternative sequence | VSP_024663 | 394-457 | in isoform 2 | |||
Sequence: EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTT → A | ||||||
Compositional bias | 619-641 | Polar residues | ||||
Sequence: SPAHHASTQGTSHRPSLPASLND | ||||||
Compositional bias | 669-683 | Polar residues | ||||
Sequence: ALSPSRQSPSSVLRD | ||||||
Compositional bias | 752-782 | Polar residues | ||||
Sequence: ATNSNAPSRSTMSSSVSSHLSSRTQVSEGAE | ||||||
Compositional bias | 784-800 | Basic and acidic residues | ||||
Sequence: SDGESHGDGDREDGGRQ | ||||||
Compositional bias | 840-858 | Polar residues | ||||
Sequence: GPRLQPSSSPQSTVPSRAH | ||||||
Compositional bias | 861-887 | Basic and acidic residues | ||||
Sequence: VPSHSDSHPKLSSGIHGDEEDEKPLPA | ||||||
Compositional bias | 904-928 | Basic and acidic residues | ||||
Sequence: RGWEDLRRSPQRGASLHRKEPIPEN | ||||||
Compositional bias | 932-971 | Polar residues | ||||
Sequence: TGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGS | ||||||
Compositional bias | 1000-1014 | Pro residues | ||||
Sequence: RAPQQQPPPPVATSQ | ||||||
Compositional bias | 1015-1074 | Polar residues | ||||
Sequence: HHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDED | ||||||
Compositional bias | 1239-1253 | Pro residues | ||||
Sequence: PVKRPLPPPPGSSPR | ||||||
Sequence conflict | 1295 | in Ref. 6; CAE51894 | ||||
Sequence: M → K | ||||||
Compositional bias | 1444-1505 | Polar residues | ||||
Sequence: THPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTP | ||||||
Sequence conflict | 1487 | in Ref. 6; CAE51894 | ||||
Sequence: P → S | ||||||
Sequence conflict | 1685 | in Ref. 6; CAE51894 | ||||
Sequence: D → N | ||||||
Sequence conflict | 1894 | in Ref. 6; CAE51894 | ||||
Sequence: W → G |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ009660 EMBL· GenBank· DDBJ | AAY26234.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL355492 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL356417 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL590551 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AB058769 EMBL· GenBank· DDBJ | BAB47495.2 EMBL· GenBank· DDBJ | mRNA | ||
BC146783 EMBL· GenBank· DDBJ | AAI46784.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC150607 EMBL· GenBank· DDBJ | AAI50608.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL832410 EMBL· GenBank· DDBJ | CAI46178.2 EMBL· GenBank· DDBJ | mRNA | ||
AJ586132 EMBL· GenBank· DDBJ | CAE51894.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |