Q4ZED2 · Q4ZED2_HUMAN

  • Protein
    Cytochrome c oxidase subunit 3
  • Gene
    COX3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      COX3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • B248
    • B328
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4ZED2

Subcellular Location

Membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-261Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    261
  • Mass (Da)
    29,935
  • Last updated
    2005-06-07 v1
  • Checksum
    8487DA9EA37C18D3
MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEIFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQTIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY882415
EMBL· GenBank· DDBJ
AAW58625.1
EMBL· GenBank· DDBJ
Genomic DNA
GU296551
EMBL· GenBank· DDBJ
ADB05095.1
EMBL· GenBank· DDBJ
Genomic DNA
GU296552
EMBL· GenBank· DDBJ
ADB05108.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703946
EMBL· GenBank· DDBJ
AFF89262.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ704796
EMBL· GenBank· DDBJ
AFG00313.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ705621
EMBL· GenBank· DDBJ
AFG11037.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171110
EMBL· GenBank· DDBJ
AFN87260.1
EMBL· GenBank· DDBJ
Genomic DNA
JX171116
EMBL· GenBank· DDBJ
AFN87338.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153657
EMBL· GenBank· DDBJ
AFO31720.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161376
EMBL· GenBank· DDBJ
AGW58460.1
EMBL· GenBank· DDBJ
Genomic DNA
KF161379
EMBL· GenBank· DDBJ
AGW58499.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162083
EMBL· GenBank· DDBJ
AGW67650.1
EMBL· GenBank· DDBJ
Genomic DNA
KF162789
EMBL· GenBank· DDBJ
AGW76828.1
EMBL· GenBank· DDBJ
Genomic DNA
MG646263
EMBL· GenBank· DDBJ
AVA29262.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687240
EMBL· GenBank· DDBJ
QLH91954.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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