Q4ZED2 · Q4ZED2_HUMAN
- ProteinCytochrome c oxidase subunit 3
- GeneCOX3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids261 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Molecular Function | cytochrome-c oxidase activity | |
Biological Process | aerobic electron transport chain |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 3
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4ZED2
Subcellular Location
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-261 | Heme-copper oxidase subunit III family profile | ||||
Sequence: QSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEIFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQTIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS |
Sequence similarities
Belongs to the cytochrome c oxidase subunit 3 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length261
- Mass (Da)29,935
- Last updated2005-06-07 v1
- Checksum8487DA9EA37C18D3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY882415 EMBL· GenBank· DDBJ | AAW58625.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU296551 EMBL· GenBank· DDBJ | ADB05095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU296552 EMBL· GenBank· DDBJ | ADB05108.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703946 EMBL· GenBank· DDBJ | AFF89262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ704796 EMBL· GenBank· DDBJ | AFG00313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ705621 EMBL· GenBank· DDBJ | AFG11037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171110 EMBL· GenBank· DDBJ | AFN87260.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX171116 EMBL· GenBank· DDBJ | AFN87338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153657 EMBL· GenBank· DDBJ | AFO31720.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161376 EMBL· GenBank· DDBJ | AGW58460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF161379 EMBL· GenBank· DDBJ | AGW58499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162083 EMBL· GenBank· DDBJ | AGW67650.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF162789 EMBL· GenBank· DDBJ | AGW76828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG646263 EMBL· GenBank· DDBJ | AVA29262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687240 EMBL· GenBank· DDBJ | QLH91954.1 EMBL· GenBank· DDBJ | Genomic DNA |