Q4Z8K6 · RBP9X_DROME
- ProteinRan-binding proteins 9/10 homolog
- GeneRanBPM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids962 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in JAK/STAT signaling. Isoform D is required for the proper arrangement of niche cells and is autonomously required for proper niche cell size, isoform C negatively regulates the adhesive properties of the niche. The germline stem cell (GSC) niche in ovaries is made up of two somatic cell types: 8-9 cells in a single-filed array make up the terminal filament (TF), and a tight cluster of 5 or 6 cap cells (CpC). Regulating the size and adhesive properties of the CpCs is an important component of the mechanism that controls their capacity to support stem cells, isoform C and isoform D are important factors in mediating this regulation. In contrast, isoform C acts as a positive regulator of cell adhesion in follicle cell epithelium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | GID complex | |
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | small GTPase binding | |
Biological Process | cytoskeleton organization | |
Biological Process | dorsal appendage formation | |
Biological Process | follicle cell of egg chamber-cell adhesion | |
Biological Process | germ-line stem-cell niche homeostasis | |
Biological Process | larval feeding behavior | |
Biological Process | negative regulation of cell adhesion | |
Biological Process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | positive regulation of protein export from nucleus |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRan-binding proteins 9/10 homolog
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ4Z8K6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Distribution varies depending on cell type and developmental stage. At late embryogenesis expression is enriched in the nuclei of follicle cells and germline cells and at the nurse cell membranes. In pupal ovaries, expression is seen in niche cells at the cell periphery. In adult ovaries expression is in the nuclei and cytoplasm of the CpCs and TF cells of the niche.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Lack of isoform D causes an increase in niche cell size and abnormal terminal filament organization. This in turn increases niche capacity by increasing the potential contact surface between CpCs and stem cells. Lack of isoform C causes defects in the organization of the follicle cell layer and defects in dorsal appendage morphogenesis.
PTM/Processing
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-246 | Disordered | |||
Compositional bias | 8-51 | Polar residues | |||
Compositional bias | 52-73 | Pro residues | |||
Compositional bias | 91-161 | Polar residues | |||
Compositional bias | 162-219 | Basic and acidic residues | |||
Compositional bias | 271-286 | Acidic residues | |||
Region | 271-296 | Disordered | |||
Region | 313-402 | Disordered | |||
Compositional bias | 315-400 | Polar residues | |||
Domain | 400-587 | B30.2/SPRY | |||
Domain | 617-649 | LisH | |||
Domain | 655-712 | CTLH | |||
Region | 800-820 | Disordered | |||
Sequence similarities
Belongs to the RANBP9/10 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q4Z8K6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameD
- SynonymsLong RanBPM
- Length962
- Mass (Da)106,654
- Last updated2005-06-07 v1
- Checksum91206B4DC4D9DB30
Q4Z8K6-2
- NameA
- Differences from canonical
- 834-835: Missing
Q4Z8K6-3
- NameC
- SynonymsShort RanBPM
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4KFL0 | A0A0B4KFL0_DROME | RanBPM | 770 | ||
A0A0B4K851 | A0A0B4K851_DROME | RanBPM | 961 | ||
A0A126GUM4 | A0A126GUM4_DROME | RanBPM | 1127 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_028296 | 1-362 | in isoform C | ||
Compositional bias | 8-51 | Polar residues | |||
Compositional bias | 52-73 | Pro residues | |||
Compositional bias | 91-161 | Polar residues | |||
Compositional bias | 162-219 | Basic and acidic residues | |||
Compositional bias | 271-286 | Acidic residues | |||
Compositional bias | 315-400 | Polar residues | |||
Sequence conflict | 445 | in Ref. 5; AAK93515 | |||
Alternative sequence | VSP_028297 | 834-835 | in isoform A and isoform C | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY973544 EMBL· GenBank· DDBJ | AAX84045.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AY973545 EMBL· GenBank· DDBJ | AAX84046.1 EMBL· GenBank· DDBJ | mRNA | ||
AY973546 EMBL· GenBank· DDBJ | AAX84047.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF58795.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | ABC66064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT011464 EMBL· GenBank· DDBJ | AAR99122.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
BT030999 EMBL· GenBank· DDBJ | ABV82381.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AY052091 EMBL· GenBank· DDBJ | AAK93515.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AY069048 EMBL· GenBank· DDBJ | AAL39193.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |