Q4WQM4 · HAS1_ASPFU

Function

function

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

Catalytic activity

Features

Showing features for binding site.

162250100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site184-191ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnuclear envelope
Cellular Componentnucleolus
Cellular Componentpreribosome, large subunit precursor
Cellular Componentsmall-subunit processome
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionidentical protein binding
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Biological Processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological ProcesssnoRNA release from pre-rRNA

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent RNA helicase has1
  • EC number

Gene names

    • Name
      has1
    • ORF names
      AFUA_4G13330

Organism names

Accessions

  • Primary accession
    Q4WQM4

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002322051-622ATP-dependent RNA helicase has1

Interaction

Subunit

Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

TypeIDPosition(s)Description
Region1-143Disordered
Compositional bias44-79Basic and acidic residues
Compositional bias104-122Basic and acidic residues
Motif140-168Q motif
Domain171-347Helicase ATP-binding
Motif294-297DEAD box
Domain361-531Helicase C-terminal
Motif373-389Bipartite nuclear localization signal
Region588-622Disordered
Compositional bias591-607Polar residues

Domain

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    622
  • Mass (Da)
    69,202
  • Last updated
    2006-04-04 v2
  • Checksum
    4C2226E7F937CE74
MSGPVDTAKSITKKRKRKHGGGARAATETDDAITRPAIENGAVNDSPEKEEDTKKSEKNGKDKSAKKRKVSHASSDEGDESQEEQGAPAQADGDSDDNKDDGNDQSEAENGDNGDKKDTESTDLPSAGTLSLPTVEGEPQKFTELGLSEKTLKAINDMGFETMTEIQRRTIPPLLAGRDVLGAAKTGSGKTLSFLIPAVEMLSALRFKPRNGTGVIVVSPTRELALQIFGVARELCQYHSQTYGIVIGGANRRAEAEKLMKGVNLLIATPGRLLDHLQNTQGFVFKNLKTLVIDEADRILEVGFEDEMRQIVKILPSEERQTMLFSATQTTKVEDLARISLRPGPLYINVDHRKEHSTVEGLEQGYVICEADKRFLLLFSFLKRNLKKKIIVFFSSCNCVKYHAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAKQGTLICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTNAKGRSLMFLQPSEVGFLKHLKEARVPVVEFEFPANKIVNVQSQLEKLIGQNYYLNKSAKEGYRSYLQAYASHSLRSVFDVHKLDLVKVAKGFGFSTPPRIDIQLGASLSRDKKQQQQGRRSYGSQPHSKGLKFKRKHDD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias44-79Basic and acidic residues
Compositional bias104-122Basic and acidic residues
Compositional bias591-607Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHF01000005
EMBL· GenBank· DDBJ
EAL89460.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp