Q4WNH8 · SET1_ASPFU
- ProteinHistone-lysine N-methyltransferase, H3 lysine-4 specific
- Geneset1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic activity
- L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
- N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
- N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | Set1C/COMPASS complex | |
Molecular Function | histone H3K4 methyltransferase activity | |
Molecular Function | histone H3K4 trimethyltransferase activity | |
Molecular Function | RNA binding | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase, H3 lysine-4 specific
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionQ4WNH8
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000269765 | 1-1241 | Histone-lysine N-methyltransferase, H3 lysine-4 specific | |||
Sequence: MSRTSAGFADFFPTAPSVLQQKRVRAPRDRPCPKDRPEDQLHVQDDNGQSSCSPGTSAANVSTNGSPPSVSVSETGTGVENSGCKLVGETNTDITGTDTSILSASLAQCRATQVNEARFDNLTPVTNAESSPPRKLSPHQSKSVEVAEYESNKFATDESKLAATPLHTPPTPRSQTSRSGVIKGCKLVYDPDLEKRSSKEKRRKPQYVDFVVNEQDGCSPDPRLSILNYTRGAGCKQKTKYRPAPYRLKQWPYDTATTIGPGPPVQIVVTGFDPLTPVAPINALFSSFGEISEINNRTDPITGRFLGVCSVKYKDSTSFRGAGPVPAATAARRAYVECKKEQRIGTRRIRVELDRDGAVSDRIVARAIESQRMGHKKNIVGEEAKVEPQAKKNEPPPTAPKGPSRSSTRPVAAVPEGPRASFLKPAIPSLIEETPILAQIKRDPYIFIAHCYVPVLSTTIPHLKKRLKLFDWKDIRCDKTGYYIIFENSRRGEEETERCFKVCHMKPLFTYIMNMESQPYGNPNYERSPSPERLQAERRERAERERLKKEADLDLEEEKKQRAIDLDPCREVLALIVRDLKDKLLEDVKSRIAAPTLYDYLDPDRHAARRRALGIPDPEGIRRHTFRLDADNFGSNNPRSFLPGDRSFSPYGLNILALPRIRKARRLNRANAAFLDERRKQPVRRKEVRPLYHRLQQLHDVDDSDEDQRTPFSRDIDEQDSRPPSRMSSRSSISDDGEESEPLDGLAPQGKRHESRLLGLEYEDSGNTLNEAVDGYSRHDSPGLSSTRKRKRVAEGIDVRKRPKEESERSQLNRSVEAGDTFYEESQHSEAAELGTVKPENLAGIGGKFLGRVEDRSINEDGEKENMERLHIESAIQGANLGIQQPLPDESTTTKSHEDPITEIEWGVSNDEPRPTVVDDETIILDLDGWQNLVKDEEDLCFLRHVLDGQSRSKVGNLSAWAWRQKEIKALNRAGESGPVHQETRIPDYYVCNPTGAARTEGRKRILESEKSKYLPHRIKVQKAREEREANAKSDPHASSAAEAARISAAKTISKSTSRSTRVNNRRLVADINAQKQALPMQGGDGDVLRFNQLKKRKKPVRFARSAIHNWGLYAEENISANDMIIEYVGEKVRQQVADMRERQYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIGRDEELTYDYKFEREWDSDDRIPCLCGSTGCKGFLN |
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-84 | Disordered | ||||
Sequence: MSRTSAGFADFFPTAPSVLQQKRVRAPRDRPCPKDRPEDQLHVQDDNGQSSCSPGTSAANVSTNGSPPSVSVSETGTGVENSGC | ||||||
Compositional bias | 23-43 | Basic and acidic residues | ||||
Sequence: RVRAPRDRPCPKDRPEDQLHV | ||||||
Compositional bias | 44-84 | Polar residues | ||||
Sequence: QDDNGQSSCSPGTSAANVSTNGSPPSVSVSETGTGVENSGC | ||||||
Compositional bias | 120-138 | Polar residues | ||||
Sequence: DNLTPVTNAESSPPRKLSP | ||||||
Region | 120-179 | Disordered | ||||
Sequence: DNLTPVTNAESSPPRKLSPHQSKSVEVAEYESNKFATDESKLAATPLHTPPTPRSQTSRS | ||||||
Compositional bias | 376-390 | Basic and acidic residues | ||||
Sequence: KKNIVGEEAKVEPQA | ||||||
Region | 376-415 | Disordered | ||||
Sequence: KKNIVGEEAKVEPQAKKNEPPPTAPKGPSRSSTRPVAAVP | ||||||
Region | 520-545 | Disordered | ||||
Sequence: YGNPNYERSPSPERLQAERRERAERE | ||||||
Compositional bias | 531-545 | Basic and acidic residues | ||||
Sequence: PERLQAERRERAERE | ||||||
Compositional bias | 686-724 | Basic and acidic residues | ||||
Sequence: KEVRPLYHRLQQLHDVDDSDEDQRTPFSRDIDEQDSRPP | ||||||
Region | 686-752 | Disordered | ||||
Sequence: KEVRPLYHRLQQLHDVDDSDEDQRTPFSRDIDEQDSRPPSRMSSRSSISDDGEESEPLDGLAPQGKR | ||||||
Region | 768-819 | Disordered | ||||
Sequence: TLNEAVDGYSRHDSPGLSSTRKRKRVAEGIDVRKRPKEESERSQLNRSVEAG | ||||||
Compositional bias | 783-813 | Basic and acidic residues | ||||
Sequence: GLSSTRKRKRVAEGIDVRKRPKEESERSQLN | ||||||
Region | 1022-1064 | Disordered | ||||
Sequence: QKAREEREANAKSDPHASSAAEAARISAAKTISKSTSRSTRVN | ||||||
Compositional bias | 1050-1064 | Polar residues | ||||
Sequence: AKTISKSTSRSTRVN | ||||||
Motif | 1062-1067 | RxxxRR motif | ||||
Sequence: RVNNRR | ||||||
Domain | 1099-1216 | SET | ||||
Sequence: KPVRFARSAIHNWGLYAEENISANDMIIEYVGEKVRQQVADMRERQYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIGRDEELTYDYK | ||||||
Domain | 1225-1241 | Post-SET | ||||
Sequence: DRIPCLCGSTGCKGFLN |
Domain
The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,241
- Mass (Da)139,368
- Last updated2005-07-05 v1
- Checksum084B0B9578429E63
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-43 | Basic and acidic residues | ||||
Sequence: RVRAPRDRPCPKDRPEDQLHV | ||||||
Compositional bias | 44-84 | Polar residues | ||||
Sequence: QDDNGQSSCSPGTSAANVSTNGSPPSVSVSETGTGVENSGC | ||||||
Compositional bias | 120-138 | Polar residues | ||||
Sequence: DNLTPVTNAESSPPRKLSP | ||||||
Compositional bias | 376-390 | Basic and acidic residues | ||||
Sequence: KKNIVGEEAKVEPQA | ||||||
Compositional bias | 531-545 | Basic and acidic residues | ||||
Sequence: PERLQAERRERAERE | ||||||
Compositional bias | 686-724 | Basic and acidic residues | ||||
Sequence: KEVRPLYHRLQQLHDVDDSDEDQRTPFSRDIDEQDSRPP | ||||||
Compositional bias | 783-813 | Basic and acidic residues | ||||
Sequence: GLSSTRKRKRVAEGIDVRKRPKEESERSQLN | ||||||
Compositional bias | 1050-1064 | Polar residues | ||||
Sequence: AKTISKSTSRSTRVN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAHF01000006 EMBL· GenBank· DDBJ | EAL88486.1 EMBL· GenBank· DDBJ | Genomic DNA |