Q4WNH8 · SET1_ASPFU

Function

function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1215S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular ComponentSet1C/COMPASS complex
Molecular Functionhistone H3K4 methyltransferase activity
Molecular Functionhistone H3K4 trimethyltransferase activity
Molecular FunctionRNA binding
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-4 specific
  • EC number
  • Alternative names
    • COMPASS component set1
    • SET domain-containing protein 1

Gene names

    • Name
      set1
    • ORF names
      AFUA_6G06335

Organism names

Accessions

  • Primary accession
    Q4WNH8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002697651-1241Histone-lysine N-methyltransferase, H3 lysine-4 specific

Interaction

Subunit

Component of the Set1C/COMPASS complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

TypeIDPosition(s)Description
Region1-84Disordered
Compositional bias23-43Basic and acidic residues
Compositional bias44-84Polar residues
Compositional bias120-138Polar residues
Region120-179Disordered
Compositional bias376-390Basic and acidic residues
Region376-415Disordered
Region520-545Disordered
Compositional bias531-545Basic and acidic residues
Compositional bias686-724Basic and acidic residues
Region686-752Disordered
Region768-819Disordered
Compositional bias783-813Basic and acidic residues
Region1022-1064Disordered
Compositional bias1050-1064Polar residues
Motif1062-1067RxxxRR motif
Domain1099-1216SET
Domain1225-1241Post-SET

Domain

The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,241
  • Mass (Da)
    139,368
  • Last updated
    2005-07-05 v1
  • Checksum
    084B0B9578429E63
MSRTSAGFADFFPTAPSVLQQKRVRAPRDRPCPKDRPEDQLHVQDDNGQSSCSPGTSAANVSTNGSPPSVSVSETGTGVENSGCKLVGETNTDITGTDTSILSASLAQCRATQVNEARFDNLTPVTNAESSPPRKLSPHQSKSVEVAEYESNKFATDESKLAATPLHTPPTPRSQTSRSGVIKGCKLVYDPDLEKRSSKEKRRKPQYVDFVVNEQDGCSPDPRLSILNYTRGAGCKQKTKYRPAPYRLKQWPYDTATTIGPGPPVQIVVTGFDPLTPVAPINALFSSFGEISEINNRTDPITGRFLGVCSVKYKDSTSFRGAGPVPAATAARRAYVECKKEQRIGTRRIRVELDRDGAVSDRIVARAIESQRMGHKKNIVGEEAKVEPQAKKNEPPPTAPKGPSRSSTRPVAAVPEGPRASFLKPAIPSLIEETPILAQIKRDPYIFIAHCYVPVLSTTIPHLKKRLKLFDWKDIRCDKTGYYIIFENSRRGEEETERCFKVCHMKPLFTYIMNMESQPYGNPNYERSPSPERLQAERRERAERERLKKEADLDLEEEKKQRAIDLDPCREVLALIVRDLKDKLLEDVKSRIAAPTLYDYLDPDRHAARRRALGIPDPEGIRRHTFRLDADNFGSNNPRSFLPGDRSFSPYGLNILALPRIRKARRLNRANAAFLDERRKQPVRRKEVRPLYHRLQQLHDVDDSDEDQRTPFSRDIDEQDSRPPSRMSSRSSISDDGEESEPLDGLAPQGKRHESRLLGLEYEDSGNTLNEAVDGYSRHDSPGLSSTRKRKRVAEGIDVRKRPKEESERSQLNRSVEAGDTFYEESQHSEAAELGTVKPENLAGIGGKFLGRVEDRSINEDGEKENMERLHIESAIQGANLGIQQPLPDESTTTKSHEDPITEIEWGVSNDEPRPTVVDDETIILDLDGWQNLVKDEEDLCFLRHVLDGQSRSKVGNLSAWAWRQKEIKALNRAGESGPVHQETRIPDYYVCNPTGAARTEGRKRILESEKSKYLPHRIKVQKAREEREANAKSDPHASSAAEAARISAAKTISKSTSRSTRVNNRRLVADINAQKQALPMQGGDGDVLRFNQLKKRKKPVRFARSAIHNWGLYAEENISANDMIIEYVGEKVRQQVADMRERQYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIGRDEELTYDYKFEREWDSDDRIPCLCGSTGCKGFLN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-43Basic and acidic residues
Compositional bias44-84Polar residues
Compositional bias120-138Polar residues
Compositional bias376-390Basic and acidic residues
Compositional bias531-545Basic and acidic residues
Compositional bias686-724Basic and acidic residues
Compositional bias783-813Basic and acidic residues
Compositional bias1050-1064Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHF01000006
EMBL· GenBank· DDBJ
EAL88486.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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