Q4WHN8 · VPS27_ASPFU

Function

function

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome membrane
Cellular ComponentESCRT-0 complex
Molecular Functionmetal ion binding
Molecular Functionphosphatidylinositol-3-phosphate binding
Molecular Functionubiquitin binding
Biological Processprotein targeting to vacuole
Biological Processprotein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar protein sorting-associated protein 27

Gene names

    • Name
      vps27
    • ORF names
      AFUA_2G04740

Organism names

Accessions

  • Primary accession
    Q4WHN8

Proteomes

Organism-specific databases

Subcellular Location

Endosome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002925081-729Vacuolar protein sorting-associated protein 27

Interaction

Subunit

Component of the ESCRT-0 complex composed of HSE1 and VPS27.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, zinc finger, compositional bias, region.

Type
IDPosition(s)Description
Domain16-147VHS
Zinc finger165-225FYVE-type; degenerate
Domain261-280UIM 1
Compositional bias276-298Polar residues
Region276-310Disordered
Domain307-326UIM 2
Region325-356Disordered
Compositional bias337-351Polar residues
Region496-729Disordered
Compositional bias520-549Polar residues
Compositional bias557-610Polar residues
Compositional bias625-690Polar residues

Domain

The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns3P) which is required for the association to endosomal membranes.
Both IUM domains are necessary for efficient binding to ubiquitin.

Sequence similarities

Belongs to the VPS27 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    729
  • Mass (Da)
    79,374
  • Last updated
    2005-07-05 v1
  • MD5 Checksum
    B4211C0FC263E8D7F1BA1AF44118E70F
MAGWFSSTSPLDEQVERATSSSLEDMALNLEISDLIRSKSVQPKEAMRSLKRRLENRNPNVQIATLKLTDTCVKNGGSHFLAEIASREFMDNLVSLLTTEGAPLNTDVKEKMLELIQDWAMAAQGRMDLNYLGETYRKLQNEGFRFPPKNEISGSMLESSAPPEWIDSDVCMRCRTPFSFMNRKHHCRNCGNVFDAQCSSKTLPLPHLGILQPVRVDDGCYVKLTSKSSLPSNLSDRSAFKNHSITKANAMEPRGARAEGGFDDDLRRALQLSLEEAQSKGSSGYVPSTRINDEPAKTTTQTNHEEEEDADLKAAIEASLRDMEEHKKKHAAALKSNAAATDSSTRDSAAATPLPKNPYELSPVEVENIHLFAALVDRLQHQPPGTILREPQIQELYESIGALRPKLARSYGETMSKHDTLLDLHAKLSTVVRYYDRMLEERLSSAYSQHSLGYATAPGGSPYPNIYPTMPSHIPEGKTGAENFYYGNPVADRAPPVGNTYGYPHSSRDIREPTAAPSGPISSGVYNQPGQAVPQNPPWNGNAPSVASPQPSAPSTPFPNNSSGYPGPSASTQYYASAPHPEQDSNAYSGPRPGETDVSHQSSPNMRRDSYYQSAGAPVTARASAPEQSPPTDQGQSPAYMQYGDSHSAQSTGQPTHQHQPTAPPPQSYYFQHQPPQSAPLPTHSQTPGAPYGTYPGGDVSPIGAPAPAVHYQPAAQTKPAVEESLIEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias276-298Polar residues
Compositional bias337-351Polar residues
Compositional bias520-549Polar residues
Compositional bias557-610Polar residues
Compositional bias625-690Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHF01000008
EMBL· GenBank· DDBJ
EAL87567.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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