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Q4WDV4 · ABCF_ASPFU

Function

function

Pleiotropic ABC efflux transporter that shows a strong substrate specificity for the azole class of drugs such as lotrimazole (CLT), fluconazole (FLC), itraconazole (ITC), ketoconazole (KTC), posaconazole (POS), econazole (ECON), metconazole (MET), miconazole (MCZ), prochloraz (PCLZ), and tebuconazole (TEBZ).

Catalytic activity

Activity regulation

The efflux inhibitor FK506 impairs the transport activity.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site865-872ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ABC multidrug transporter F

Gene names

    • Name
      abcF
    • ORF names
      AFUA_5G00790

Organism names

Accessions

  • Primary accession
    Q4WDV4

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane498-518Helical
Transmembrane532-552Helical
Transmembrane578-598Helical
Transmembrane607-627Helical
Transmembrane641-661Helical
Transmembrane751-771Helical
Transmembrane1167-1187Helical
Transmembrane1201-1221Helical
Transmembrane1252-1272Helical
Transmembrane1288-1308Helical
Transmembrane1326-1346Helical
Transmembrane1441-1461Helical

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004526591-1471ABC multidrug transporter F
Glycosylation4N-linked (GlcNAc...) asparagine
Glycosylation71N-linked (GlcNAc...) asparagine
Glycosylation311N-linked (GlcNAc...) asparagine
Glycosylation519N-linked (GlcNAc...) asparagine
Glycosylation842N-linked (GlcNAc...) asparagine
Glycosylation1386N-linked (GlcNAc...) asparagine
Glycosylation1422N-linked (GlcNAc...) asparagine
Glycosylation1429N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-18Polar residues
Region1-40Disordered
Compositional bias21-40Basic and acidic residues
Domain133-387ABC transporter 1
Region791-819Disordered
Domain829-1071ABC transporter 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,471
  • Mass (Da)
    164,620
  • Last updated
    2005-07-05 v1
  • MD5 Checksum
    DF04A12977FBB2951F70357B0BB5675B
MALNSTDNRWSTGEDTPSEAQLPDGEERLDAAPDEKVTAEDIDRRLTNLVRKISAQSRRSHHSFLFGAGENSSLNPQSPSFDARKWARAFYNARYRQDDGHPPRVVGVAFKNLNVFGYGSPVDYQMSVGNALLKVPTMVRQALGGGKQRVDILHDVEGLVLPGEQLCVLGPPGSGCSTFLRTIAGETHGLNVDAASYINYHGISPKQMSTAFRGEAIYTAEVDAHFPMLSVGDTLYFAALARAPQVIPGGLSRQEYAKHLRDVIMAMFGIGHTINTRVGNDFVRGVSGGERKRVTIAEAALGYSPLQCWDNSTRGLDSANAVEFCRTLRTQSDVFGITSCVAIYQAPQAAYDLFDKVLVLYEGWQIYFGAAHEAQAYFEQLGFQCPESQTTADFLTSMCSPAERIVKPGFEHMAPRTPEEFAQRWKESPQRQSLLHAIEKYSTEHPLDGPDLHQFALSRRAEKSHRQREKSPYTLSYRGQVKLCLWREWQRLKNDPSVTLAMLIGNFFEALIIASIFYNLTGDTSSFYYRGALLFMMVLLNAFASVLEILTLYEKRTIVEKQSRYAYYHPSAEALSSFIMSLPYKFVNSSLVNLTLYFMSNLRREPGPFFFFLLISTSMMLAMSMFFRWFASLTKTIDQALAPSSIILLALVLYTGFTIPVSYMRGWASWIRWLNPVSYGFEAVMINEFHGREFPCSSFVPSGPGYEDVSRTQRVCSTVGATSGSDVVSGDVFVRSSYGYVNSHRWRNFGIIIAMTVFLAVCHFVTTELVASKRSKGEVLVFRRGSAHIARAKQGQRDEEQPSASAVPSEKYSEAPTPVEGVETQTSIFHWEDVCYDVKIKNETRRILDHVDGWIKPGTLTALMGVSGAGKTTLLDVLASRTTVGVVTGETLVDGRQRDSSFQRKTGYVQQQDLHLATTTVREALEFSALLRQPPQYSREEKLEYVEKVIDLLHMRDYADAIVGVPGEGLNVERRKRLTIGVELAARPKLLLFLDEPTSGLDSQTSWSICNLMETLTRNGQAILCTIHQPSAMLFQRFDRLLLLAKGGKTVYFGEIGSGARTLMDYFVRNGGPPCPKGANPAEHMLEVIGAAPGAHTDIDWPAVWRNSPEYQQVRQELSRLRQLASQPSSVHSDDPSSYSEFAAPFPAQLGQVGRRVFQQYWRTPSYLYSKAILTVGSSIFIGFSFFKGDNTAQGLQNQVFGVFVFLFVVIQLIFQIIPTFVTQRTLYESRERQSKTYSWQAFVLSNIAVEFAWNTIAAVLCFLAWFYPVGLYRNAEYTDSVHSRSTLVFLIIWATFLFASSFAHLLIAGVESAELASALANIMGIMMYAFCGILAGPHALPGFWIFMYRVNPFTYLVSGLLSASLGDAPMHCAANEFLAFSPPANRTCGEYMEDYMALAGGYLLDSAARGDEQCQYCRVDNTSQYLRNFSIDFATRWRDFGLLWVYVAVNTFGAVFLYWLCRVPKGKKRL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues
Compositional bias21-40Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHF01000011
EMBL· GenBank· DDBJ
EAL86223.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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