Q4VYA5 · HIUH_SALDU

  • Protein
    5-hydroxyisourate hydrolase
  • Gene
    hiuH
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).

Miscellaneous

Despite its homology to transthyretins, is not able to bind to the thyroid hormones thyroxine (T4) and triiodothyronine (T3).
HIU hydrolysis also occurs spontaneously, but more slowly.

Catalytic activity

Features

Showing features for binding site.

1136102030405060708090100110120130
TypeIDPosition(s)Description
Binding site31substrate
Binding site69substrate
Binding site133substrate

GO annotations

AspectTerm
Cellular Componentperiplasmic space
Molecular Functionhydroxyisourate hydrolase activity
Biological Processpurine nucleobase metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-hydroxyisourate hydrolase
  • EC number
  • Short names
    HIU hydrolase; HIUHase
  • Alternative names
    • Transthyretin-like protein (TLP)
    • Transthyretin-related protein (TRP)

Gene names

    • Name
      hiuH
    • Synonyms
      yedX

Organism names

  • Taxonomic identifier
  • Strain
    • 2229
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    Q4VYA5
  • Secondary accessions
    • O85301

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis31Loss of activity.
Mutagenesis120Reduces activity by 90%.
Mutagenesis133Reduces activity by 90%.

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500007493423-1365-hydroxyisourate hydrolase

Interaction

Subunit

Homotetramer.

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    136
  • Mass (Da)
    15,105
  • Last updated
    2005-07-05 v1
  • Checksum
    6515448D6B1F889D
MKRHILATVIASLVAAPAMALAAGNNILSVHILDQQTGKPAPGVEVVLEQKKDNGWTQLNTGHTDQDGRIKALWPEKAAAPGDYRVIFKTGQYFESKKLDTFFPEIPVEFHISKTNEHYHVPLLLSQYGYSTYRGS

Sequence caution

The sequence AAC33718.1 differs from that shown. Reason: Frameshift

Mass Spectrometry

Molecular mass is 12,872 Da. Determined by Electrospray.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF060858
EMBL· GenBank· DDBJ
AAC33718.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
AJ972893
EMBL· GenBank· DDBJ
CAI99863.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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