Q4VWI5 · Q4VWI5_THALA

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

136850100150200250300350
TypeIDPosition(s)Description
Binding site79Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site93Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site178Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site192Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site197a ubiquinone (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • 1561
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Sigmodontinae > Thalpomys

Accessions

  • Primary accession
    Q4VWI5

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-48Helical
Transmembrane77-99Helical
Transmembrane111-129Helical
Transmembrane136-154Helical
Transmembrane174-196Helical
Transmembrane225-242Helical
Transmembrane284-303Helical
Transmembrane315-335Helical
Transmembrane341-362Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-205Cytochrome b/b6 N-terminal region profile
Domain206-368Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    368
  • Mass (Da)
    41,303
  • Last updated
    2005-07-05 v1
  • Checksum
    4681E3A041646F00
RKNHPLLKIMNHSFIDLPTPSNISSWWNXGSLLGICLMIQILTGLFLAMHYTSDTATAFSSVVHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYVLSETWNIGIILLLTTMATAFVGYVLPWGQMSLWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAFVLVHLLFLHETGSNNPSGLNSDSDKIPFHPYYTIKDLLGILLLLMVLIILALFFPDALGDPDNYIPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILATFPLLNNSKQHGLIFRPISQIIYWTFVANLLVLTWIGGQPVEYPFTVIGQIASISYFTIIIILMPMSKLS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue368

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY310353
EMBL· GenBank· DDBJ
AAQ90240.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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