Q4VA61 · DSCL1_MOUSE

  • Protein
    Cell adhesion molecule DSCAML1
  • Gene
    Dscaml1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (PubMed:19945391).
Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functioncell-cell adhesion mediator activity
Biological Processaxon guidance
Biological Processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Biological Processcentral nervous system development
Biological Processdendrite self-avoidance
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules
Biological Processnegative regulation of cell adhesion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cell adhesion molecule DSCAML1
  • Alternative names
    • Down syndrome cell adhesion molecule-like protein 1 homolog

Gene names

    • Name
      Dscaml1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q4VA61

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Synapse

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain19-1591Extracellular
Transmembrane1592-1612Helical
Topological domain1613-2053Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

The inner nuclear and inner plexiform layers in the retina are disorganised at postnatal day 20 (P20). AII amacrine cell populations are randomly distributed or pulled into clumps and rod bipolar show fasciculated dendrites.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 82 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000039248019-2053Cell adhesion molecule DSCAML1
Disulfide bond47↔103
Glycosylation79N-linked (GlcNAc...) asparagine
Disulfide bond146↔198
Disulfide bond247↔294
Disulfide bond336↔386
Glycosylation368N-linked (GlcNAc...) asparagine
Disulfide bond429↔485
Glycosylation471N-linked (GlcNAc...) asparagine
Disulfide bond526↔575
Disulfide bond617↔669
Glycosylation666N-linked (GlcNAc...) asparagine
Glycosylation710N-linked (GlcNAc...) asparagine
Disulfide bond711↔767
Glycosylation809N-linked (GlcNAc...) asparagine
Disulfide bond810↔867
Glycosylation1144N-linked (GlcNAc...) asparagine
Glycosylation1162N-linked (GlcNAc...) asparagine
Disulfide bond1311↔1363
Glycosylation1345N-linked (GlcNAc...) asparagine
Glycosylation1561N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the retina, expressed in the rod photoreceptors, AII amacrine cells and rod bipolar cells (at protein level).

Gene expression databases

Interaction

Subunit

Homodimer; mediates homophilic interactions to promote cell adhesion.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain19-119Ig-like C2-type 1
Domain115-217Ig-like C2-type 2
Domain226-310Ig-like C2-type 3
Domain314-396Ig-like C2-type 4
Domain408-501Ig-like C2-type 5
Domain506-586Ig-like C2-type 6
Domain596-685Ig-like C2-type 7
Domain690-784Ig-like C2-type 8
Domain788-885Ig-like C2-type 9
Domain887-984Fibronectin type-III 1
Domain989-1088Fibronectin type-III 2
Domain1093-1189Fibronectin type-III 3
Domain1193-1288Fibronectin type-III 4
Domain1278-1377Ig-like C2-type 10
Domain1383-1477Fibronectin type-III 5
Domain1478-1578Fibronectin type-III 6
Region1716-1741Disordered
Compositional bias1726-1741Polar residues
Region1773-1803Disordered
Region1840-1862Disordered
Region1974-2053Disordered
Compositional bias1979-2011Pro residues
Compositional bias2032-2053Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    2,053
  • Mass (Da)
    224,240
  • Last updated
    2010-03-23 v2
  • Checksum
    0C0806C47D7ADCD6
MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQHVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLFPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRIKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSITPENRFFITSHGGLYISDVQKEDALSTYRCITQHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWTGHSVELPCAASGYPIPAIRWLKDGRPLPADSRWAKRITGLTISDLRTEDSGTYICEVTNTFGSAEANGILTVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNSVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKAMFLTVKIPAMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNVTTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSLDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGVRANSSTEVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFVVRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPALIQSTGPLIDMSDIRPGTNPVSRKNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYTKSEAFFRKADGREPCPVVPPREASMRNLTRAYHTQARHLTLDPASKPLGLPHPGATAATATATLPQRTLAMPAPPAGTAPPAPGPTPSEPSAAPSAAPPAPSTEPPRAGGPHTKMGGSRDSLLEMSTPGVGRSQKQGAGAYSKSYTLV

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1L1SQZ7A0A1L1SQZ7_MOUSEDscaml1286
A0A1L1SQ53A0A1L1SQ53_MOUSEDscaml134
E9QPR7E9QPR7_MOUSEDscaml12111

Sequence caution

The sequence AAH96527.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1726-1741Polar residues
Compositional bias1979-2011Pro residues
Compositional bias2032-2053Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC119237
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC159893
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC174644
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC126804
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC096527
EMBL· GenBank· DDBJ
AAH96527.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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