Q4V8K2 · CTBL1_RAT
- ProteinBeta-catenin-like protein 1
- GeneCtnnbl1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids563 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | Prp19 complex | |
Cellular Component | spliceosomal complex | |
Molecular Function | enzyme binding | |
Biological Process | adaptive immune response | |
Biological Process | mRNA processing | |
Biological Process | positive regulation of apoptotic process | |
Biological Process | RNA splicing | |
Biological Process | somatic diversification of immunoglobulins |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-catenin-like protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ4V8K2
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000239450 | 1-563 | Beta-catenin-like protein 1 | |||
Sequence: MDVGELLSYQPNRGTKRPRDDEEEELKTRRKQTGPRERGRYREDEATAAEDADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELSAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVREEADGVHNTLAIVENMAEFRPEMCTEAAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDALCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGADNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDIVRRGEIIDNDMEDEFYLRRLDAGLFILQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRETEQKRILGLLENF | ||||||
Modified residue | 91 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 389 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 545 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, repeat, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-81 | Disordered | ||||
Sequence: MDVGELLSYQPNRGTKRPRDDEEEELKTRRKQTGPRERGRYREDEATAAEDADDDKKRLLQIIDRDGEEEEEEEEPLDESS | ||||||
Compositional bias | 14-65 | Basic and acidic residues | ||||
Sequence: GTKRPRDDEEEELKTRRKQTGPRERGRYREDEATAAEDADDDKKRLLQIIDR | ||||||
Motif | 16-33 | Nuclear localization signal | ||||
Sequence: KRPRDDEEEELKTRRKQT | ||||||
Repeat | 79-129 | HEAT 1 | ||||
Sequence: ESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVAT | ||||||
Motif | 130-140 | Nuclear export signal (NES) | ||||
Sequence: MPDLYHLLVEL | ||||||
Repeat | 134-176 | HEAT 2 | ||||
Sequence: YHLLVELSAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHE | ||||||
Repeat | 178-228 | ARM 1 | ||||
Sequence: EEGAEVLIDALVDGQVVALLVQNLERLDESVREEADGVHNTLAIVENMAEF | ||||||
Repeat | 229-273 | ARM 2 | ||||
Sequence: RPEMCTEAAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDN | ||||||
Repeat | 274-323 | ARM 3 | ||||
Sequence: DENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDALCSCLML | ||||||
Repeat | 325-363 | ARM 4 | ||||
Sequence: SNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIG | ||||||
Repeat | 364-417 | ARM 5 | ||||
Sequence: PEGADNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRN | ||||||
Coiled coil | 476-540 | |||||
Sequence: DMEDEFYLRRLDAGLFILQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENI |
Domain
The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length563
- Mass (Da)64,948
- Last updated2005-07-05 v1
- Checksum7363EFB389CFFD80
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AHN5 | A0A8I6AHN5_RAT | Ctnnbl1 | 570 | ||
A0A8I6A264 | A0A8I6A264_RAT | Ctnnbl1 | 556 | ||
A0A8L2QUN4 | A0A8L2QUN4_RAT | Ctnnbl1 | 564 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 14-65 | Basic and acidic residues | ||||
Sequence: GTKRPRDDEEEELKTRRKQTGPRERGRYREDEATAAEDADDDKKRLLQIIDR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC097352 EMBL· GenBank· DDBJ | AAH97352.1 EMBL· GenBank· DDBJ | mRNA |