Q4V847 · INT8_XENLA

Function

function

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentintegrator complex
Biological ProcesssnRNA 3'-end processing

Names & Taxonomy

Protein names

  • Recommended name
    Integrator complex subunit 8
  • Short names
    Int8

Gene names

    • Name
      ints8

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q4V847

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002595551-991Integrator complex subunit 8

Expression

Gene expression databases

    • 734502Expressed in neurula embryo and 19 other cell types or tissues

Interaction

Subunit

Belongs to the multiprotein complex Integrator.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, repeat.

TypeIDPosition(s)Description
Region1-22Disordered
Repeat250-288TPR 1
Repeat319-355TPR 2
Repeat569-602TPR 3
Repeat829-862TPR 4

Sequence similarities

Belongs to the Integrator subunit 8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    991
  • Mass (Da)
    112,618
  • Last updated
    2005-07-05 v1
  • Checksum
    C9311DA3988D24C6
MSAEAADREAATSSRPCTPPQTSWFEFLLDDSLLEKHLQKPHSDPPPVQLIVQFLEQASKPTLNEQNQVQPPTDNKRNRTLKLLALKVAAHLKWNLDVLEKSLSVPVLNMLLNELLCASKVPPGTKHVDLDLSTLPPTTVMAVTLYNRWAIRTIVQSGFPVKPVKQGPQQPNVMNQIQQEKELTENILKVLKEQAEDSITVLEGALQLKRDFYVHTMRTLDLLAVEPGMVNGETENSTAGFKISSDEMQCQGCYDLGAVYFLQGPTNPSCYEKARDHFFRTKQLVSKIGAASDHYAIDEKRLAGYCQACGVLAPSNVVSQPATPYSQIHNFMKTNNYQGILKIFLEDHLNNSLPDQFRQSVLRELFQKSQQGNGALAELCFKVCACNTVYDILHGQPVTVQFHQLFMKPSKEKIDFLLEVCSRSLMSDQASEASKRKIATFLKNLCLEIEDLQLVFMISSHELFMKMLTDEESKMVVEHLRKKTSRVSMCTKPITSFYDIPASASVNIGQLEHQLILTVDPWRIRQILIELHGMTSDRQYWKVSSKWEVPTIYSGSILGIKDNLTRDLVYILLAKGLHCSAIKDYPRAKQLLSACLELVTEFSPKLRQVMLNEMLLLDIYTYEAVSAQERPPPELISRVRGYLEMRIPDIPLRQVVAEECVAFLLNWRENECLTLQVPASLVQSNPYVKLGQLLAATCKELPGPDSRRTAKDLWEVVVQICSVSNQHKRNNDGRVCLIKNRDSTMGIMYRNELVSFIKKLREPLVLTTLLSLFVKLHNLREDIVNDITAEHISIWPSCIPNLQAVDFDAVAVTVKELVSYALTINSNSHSWLTIQADIYFATNEYSAALNYYLQAGAVCSDFFTKQVPPEVYTDQVIKRMIKCCSMLNCHTQVAILCQFLREIDYKTAFKALQEQNSHDGMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPDEVLQLAAQRRKKKFLQSMAKLYF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC097549
EMBL· GenBank· DDBJ
AAH97549.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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