Q4V7D6 · NIF3L_RAT

  • Protein
    NIF3-like protein 1
  • Gene
    Nif3l1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functionidentical protein binding
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuron differentiation
Biological Processpositive regulation of DNA-templated transcription

Names & Taxonomy

Protein names

  • Recommended name
    NIF3-like protein 1

Gene names

    • Name
      Nif3l1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q4V7D6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Interaction with COPS2 may regulate localization to the nucleus.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003309091-376NIF3-like protein 1
Modified residue108N6-acetyllysine
Modified residue254Phosphothreonine
Modified residue258Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer (By similarity).
Interacts with COPS2 (PubMed:12522100).
Interacts with THOC7 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region243-376Mediates interaction with COPS2

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    41,519
  • Last updated
    2005-07-05 v1
  • Checksum
    026B28FA7CC412B3
MLSSAHVVPTSVRRAPSWICSSSRSFMDLKALLSSLNDFASLSFAESWDNVGLLVEPSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKTWKERLVIRALENRVAIYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPSKAPNYPTEGTHRLEFSANHSQDLDKVMSAVKGVGGVSVTSFPARCDGEEQTRVSLNCTQKALMQVLAFLSQDRQLYQKTEILSLEKPLLLHTGMGRLCTLDESVSLATMIERIKRHLKLPHLRLALGVGRTLESPVKVVALCAGSGGSVLQGVEADLYLTGEMSHHDVLDAASKGINVILCEHSNTERGFLSDLQEMLGVHLENKINIILSETDRDPLRVV

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8L2Q986A0A8L2Q986_RATNif3l1386
A0A8I6A868A0A8I6A868_RATNif3l1356
Q4V8D5Q4V8D5_RATNif3l1335

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC097992
EMBL· GenBank· DDBJ
AAH97992.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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