Q4V321 · GAG13_HUMAN
- ProteinG antigen 13
- GeneGAGE13
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids117 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Miscellaneous
This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameG antigen 13
- Short namesGAGE-13
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4V321
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Variants
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The viewer provides 153 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000252476 | 1-117 | UniProt | G antigen 13 | |||
Sequence: MSWRGRSTYYWPRPRRYVEPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC | |||||||
Modified residue (large scale data) | 33 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 40 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 115 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-117 | Disordered | ||||
Sequence: MSWRGRSTYYWPRPRRYVEPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC | ||||||
Compositional bias | 99-117 | Basic and acidic residues | ||||
Sequence: PPNPEEVKTPEEGEKQSQC |
Sequence similarities
Belongs to the GAGE family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length117
- Mass (Da)12,957
- Last updated2018-03-28 v2
- Checksum375ACB1AF3800671
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 11 | in Ref. 1; CAI95426 | ||||
Sequence: W → R | ||||||
Sequence conflict | 50 | in Ref. 1; CAI95426 | ||||
Sequence: R → C | ||||||
Compositional bias | 99-117 | Basic and acidic residues | ||||
Sequence: PPNPEEVKTPEEGEKQSQC | ||||||
Sequence conflict | 112 | in Ref. 1; CAI95426 | ||||
Sequence: E → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC233302 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX649339 EMBL· GenBank· DDBJ | CAI95426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF235097 EMBL· GenBank· DDBJ | CAI95426.1 EMBL· GenBank· DDBJ | Genomic DNA |