Q4UZF6 · CLP_XANC8
- ProteinCRP-like protein Clp
- Geneclp
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids230 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway.
Activity regulation
Allosterically inhibited by cyclic di-GMP (c-di-GMP), which binds to Clp and abolishes its ability to bind its target gene promoter.
Features
Showing features for binding site, dna binding.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | protein-DNA complex | |
Molecular Function | catalytic activity | |
Molecular Function | cyclic-di-GMP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription activator activity | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | protein dimerization activity | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCRP-like protein Clp
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionQ4UZF6
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 99 | No change in DNA-binding, but decrease in response to c-di-GMP. | ||||
Sequence: E → S | ||||||
Mutagenesis | 149 | No change in DNA-binding and in response to c-di-GMP. | ||||
Sequence: T → S |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405702 | 1-230 | CRP-like protein Clp | |||
Sequence: MSLGNTTVVTTTVRNATPSLTLDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVILRTRTQCELAEISYERLQQLFQTSLSPDAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR |
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 158-230 | HTH crp-type | ||||
Sequence: LDVTDRIVRTLHDLSKEPEAMSHPQGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR |
Domain
Binding of c-di-GMP appears to trigger the active Clp conformation into an open form or inactive state, hence abolishing its DNA-binding ability.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length230
- Mass (Da)25,711
- Last updated2005-07-05 v1
- ChecksumF9252D2A1D2C1F0B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000050 EMBL· GenBank· DDBJ | AAY47567.1 EMBL· GenBank· DDBJ | Genomic DNA |