Q4U110 · Q4U110_MOUSE
- ProteinNF-kB RelB splice variant 3
- GeneRelb
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q4U110
Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.
- CategoriesFunction, Expression, Interaction
- SourceMGI: 103289
- PubMed
- Europe PMC
- Oncogene 9:3289-3297 ()
Mapped toE3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-kappaB activation.
- CategoriesFunction, PTM / Processing, Interaction
- SourceMGI: 103289
Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.
- AnnotationEda-activated RelB recruits BAF complex to specific gene loci for local chromatin remodeling of target genes.
- CategoriesFunction, Interaction
TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-kappaB signaling.
- AnnotationStudy findings demonstrate that RelB involved in noncanonical NF-kappaB signaling is upregulated by TRAF2 and is required for mediating the cytoprotective effects of TRAF2 overexpression in mouse model of myocardial infarction. Cytoprotective effects of TRAF2 are mediated by crosstalk between the canonical and noncanonical NF-kappaB signaling pathways thereby revealing a complexity for NF-kappaB signaling in the heart.
- CategoriesFunction, Interaction
Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation.
- CategoriesFunction, Interaction
- SourceMGI: 103289
The NF-kappaB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.
- Annotationresults suggest that changes in the relative concentrations of RelB NIK:IKK1 and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100.
- CategoryInteraction
- SourceGeneRif: 19698
Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKalpha Phosphorylation.
- Annotationphosphorylation of DBC1 at its C terminus by IKKalpha facilitates its interaction with RelB and IKKalpha indicating that DBC1-mediated suppression of alternative NF-kappaB is regulated by IKKalpha.
- CategoryInteraction
- SourceGeneRif: 19698
IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors.
- CategoriesFunction, PTM / Processing, Interaction
- SourceMGI: 103289
The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression.
- CategoryInteraction
- SourceMGI: 103289
An atlas of combinatorial transcriptional regulation in mouse and man.
- CategoriesFunction, PTM / Processing, Interaction
- SourceMGI: 103289
Stabilization of RelB requires multidomain interactions with p100/p52.
- AnnotationThese unique protein-protein contacts explain why RelB prefers p52 as its dimeric partner for transcriptional activity and is retained in the cytoplasm as an inhibited complex by p100.
- CategoryInteraction
RelB, a new Rel family transcription activator that can interact with p50- NF-kappa B.
- CategoryInteraction
- SourceMGI: 103289
NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB.
- AnnotationIn the absence of p50 p52 and RelB can compensate for p50 in TNF-stimulated growth and cyclin D1 induction in mammary epithelial cells
- CategoryInteraction
Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
- CategoryInteraction
- SourceMGI: 103289
Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter.
- AnnotationConstitutive association of VDR with the relB promoter was demonstrated in dendritic cells; association of HDAC3 and HDAC1 with the relB VDR-binding site was observed but only HDAC3 was reciprocally modulated by D(3) analog and LPS
- CategoryInteraction
- SourceGeneRif: 19698
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
- AnnotationResults identify a novel type of NF-kappaB-binding site in IkappaB kinase alpha-dependent chemokine gene promoters that is preferentially recognized by RelB:p52 dimers.
- CategoryInteraction
RelB/p50 dimers are differentially regulated by tumor necrosis factor- alpha and lymphotoxin-beta receptor activation: critical roles for p100.
- Annotationp100 regulates the binding activity of RelB/p50 dimers via at least two distinct mechanisms depending on the signaling pathway involved.
- CategoryInteraction
RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF.
- Annotationrole in Peyer's patch development along with p50 and p52 focusing on lymphotoxin and tumor necrosis factor signal transduction
- CategoryInteraction