Q4SPP3 · Q4SPP3_TETNG

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      GSTENG00014734001

Organism names

Accessions

  • Primary accession
    Q4SPP3

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-31Helical
Transmembrane52-74Helical
Transmembrane80-104Helical
Transmembrane180-206Helical
Transmembrane237-263Helical
Transmembrane275-295Helical
Transmembrane301-321Helical
Transmembrane328-350Helical
Transmembrane474-495Helical
Transmembrane516-538Helical
Transmembrane544-564Helical
Transmembrane571-591Helical
Transmembrane603-625Helical
Transmembrane632-657Helical
Transmembrane663-682Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-432Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    685
  • Mass (Da)
    75,213
  • Last updated
    2005-07-19 v1
  • Checksum
    DA15716B4DE6D6AF
LRAICDPNHLSHRVVVLAFMCFLGFGSYFCFDNPAALQTQVIKDLDLNTAKFMQLYAWYSWPNVVLCFFGGFLIDRVFGIRLGTIIFSLFVCVGQVIFATGALVNRFWLCEVGRFVFGIGGESLAVAQNTYAVNWFKGKELNLVFGLQLSMARLGSTVNMNIMGSVYSRITDLVGSPGHFTLGISLMIGGLPCLFSLLCALVLGFLDRRAEKILHKEEGKTGEVIKLTDVKDFPLPLWLIFIICVGYYVAIFPFIGLGQVFFIEKFNFSPAEARAVNSIVYIISAPASPVLGFLVDKTGRNVIWVLIAVVTTLAAHMMLAFTFWNPWIAMSVLGASYSLLACVLLPMVAFVVPEHQVGTAYGFMQSIQNLGLALIAMAAGTILDTRGYLILEVDSAKLTPMSAFGLRNRYLSRLGAQISMPMFFLFLHSASTPLLHPSVITCPQERPEVKPLRRHSALCLGTTEDLDLSTAEFMVLYSCYAWPNVVLCFFGGFLIDRVFGIRVFFIEKFNFSLAEARAVNSIVYLISAPASLVLGFLVNKTGRNVIWVLIAVVTTLAAHMMLAFTFWNPWIAMSVLGASCSVVACVLWPMVAFVVPEHQLGTAYGFMQSIQNLGLALIAMAAGTILDTRGYLILEVFFCTCVCSECFCVCVSVLVLLGLWMTSGFFCLSFLDGGGGAVLCGLSQR

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAAE01014537
EMBL· GenBank· DDBJ
CAF97389.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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