Q4RSB2 · Q4RSB2_TETNG

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

GO annotations

AspectTerm
Cellular Componentperinuclear region of cytoplasm
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processintracellular signal transduction
Biological Processlipid catabolic process
Biological Processsingle fertilization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoinositide phospholipase C
  • EC number

Gene names

    • Name
      PLCz1
    • ORF names
      GSTENG00029777001

Organism names

Accessions

  • Primary accession
    Q4RSB2

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region246-275Disordered
Compositional bias252-271Acidic residues
Domain293-408PI-PLC Y-box
Domain409-533C2

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    551
  • Mass (Da)
    62,958
  • Last updated
    2005-07-19 v1
  • Checksum
    38CE594D538EA4E0
MLRRSKPPSTRRADIQQLYQRYLSDATLSAANLLQFLHKEQKELTADEDTTKRLIQRYEIEHSAIEAKSMTFEGFFRYMESKECCVFNQAHTSVYQDMDQPLSSYFISSSHNTYLTGDQLVGKSHLDAYVCALRKGCRCLEIDCWDGADMEPVVYHGYTLTTKILFKEVITTVEQHAFEKSPYPVILSLENHCCKEQQEIMAHYLVSILGEKLLRAPIDHPATGELPSPNDLKHKILIKNKKLKPKTEAEESVDEGEDEEEEEDEEEEEEEETKKLKFCSSRMTGSKKIVKALSDLVVYTRSVKFCSFTHSRDNQHSYENTSLEENKARKLLKSSGADFVGHNQRFLSRIYPAGSRTSSSNYNPQEFWNVGCQLVALNFQSLAAPMDLNDGRFQDNGGCGYVLKPVVLMSSQGCFDPRRSQRRVRPVHLLLKVISGSNLPILKSRKSLDPFVKVEIHGIPSDSSKQSTHTVKNNSLSPHWDAHMNFKISTPELCLIRFCVRDQTGLLSSEFVGQYTLPFTSLMKGYRWVPLWSRDGCSLDPASLFVFVWYS

Features

Showing features for compositional bias, non-terminal residue.

TypeIDPosition(s)Description
Compositional bias252-271Acidic residues
Non-terminal residue551

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ185299
EMBL· GenBank· DDBJ
ADX05669.1
EMBL· GenBank· DDBJ
mRNA
CAAE01015000
EMBL· GenBank· DDBJ
CAG08720.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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