Q4QY71 · RSSA_SPAAU
- ProteinSmall ribosomal subunit protein uS2
- Generpsa
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids304 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
Miscellaneous
This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 115-116 | Cleavage; by ST3; site 1 | ||||
Sequence: AF | ||||||
Site | 133-134 | Cleavage; by ST3; site 2 | ||||
Sequence: PL |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | laminin binding | |
Molecular Function | laminin receptor activity | |
Molecular Function | structural constituent of ribosome | |
Biological Process | ribosomal small subunit assembly | |
Biological Process | translation |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSmall ribosomal subunit protein uS2
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Spariformes > Sparidae > Sparus
Accessions
- Primary accessionQ4QY71
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000371572 | 2-304 | Small ribosomal subunit protein uS2 | |||
Sequence: SGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMDQYVYKRKSDGVYIINLKKTWEKLLLAARAIVAIENPADVCVISSRNTGQRAVLKFASATGATTFHGRFTPGTFTNQIQAAFREPRLLIVTDPRADHQPLTEASYVNIPTIALCNTDSPLRYVDIAIPCNNKGHHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVGKEEFQGEWSAPAAEFTQPEVADWSEGVAVPSVPIQQFPAGTPAPAPAVKTEDWSTQPATEDWSTAPTAQASDWGGATSDWS |
Post-translational modification
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Keywords
- PTM
Interaction
Subunit
Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps21. Interacts with several laminins including at least lamb1. Interacts with mdk.
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 161-180 | Laminin-binding | ||||
Sequence: IPCNNKGHHSVGLMWWMLAR | ||||||
Region | 205-229 | Laminin-binding | ||||
Sequence: RDPEEIEKEEQAAAEKAVGKEEFQG | ||||||
Repeat | 230-232 | [DE]-W-[ST] 1 | ||||
Sequence: EWS | ||||||
Region | 242-304 | Laminin-binding | ||||
Sequence: EVADWSEGVAVPSVPIQQFPAGTPAPAPAVKTEDWSTQPATEDWSTAPTAQASDWGGATSDWS | ||||||
Repeat | 245-247 | [DE]-W-[ST] 2 | ||||
Sequence: DWS | ||||||
Region | 257-304 | Disordered | ||||
Sequence: IQQFPAGTPAPAPAVKTEDWSTQPATEDWSTAPTAQASDWGGATSDWS | ||||||
Repeat | 275-277 | [DE]-W-[ST] 3 | ||||
Sequence: DWS | ||||||
Compositional bias | 275-304 | Polar residues | ||||
Sequence: DWSTQPATEDWSTAPTAQASDWGGATSDWS | ||||||
Repeat | 284-286 | [DE]-W-[ST] 4 | ||||
Sequence: DWS | ||||||
Repeat | 302-304 | [DE]-W-[ST] 5 | ||||
Sequence: DWS |
Sequence similarities
Belongs to the universal ribosomal protein uS2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length304
- Mass (Da)33,610
- Last updated2009-05-05 v2
- Checksum08F7A8DBC2C09EF6
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A671YIP0 | A0A671YIP0_SPAAU | LOC115576191 | 347 | ||
A0A671YHZ9 | A0A671YHZ9_SPAAU | LOC115576191 | 293 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 275-304 | Polar residues | ||||
Sequence: DWSTQPATEDWSTAPTAQASDWGGATSDWS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY550956 EMBL· GenBank· DDBJ | AAT44424.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |