Q4QSC5 · NQO9_RHOMR

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site73[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site76[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site79[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site83[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site113[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site116[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site119[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site123[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane respiratory chain complex I
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological Processaerobic respiration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit 9
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit 9
    • NDH-1 subunit 9

Gene names

    • Name
      nqo9

Organism names

Accessions

  • Primary accession
    Q4QSC5

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002457391-230NADH-quinone oxidoreductase subunit 9

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits Nqo7-14 constitute the membrane sector of the complex (By similarity).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain60-934Fe-4S ferredoxin-type 1
Domain104-1334Fe-4S ferredoxin-type 2

Sequence similarities

Belongs to the complex I 23 kDa subunit family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    230
  • Mass (Da)
    27,120
  • Last updated
    2005-07-19 v1
  • Checksum
    E951770E49179E57
MPGKPVNLASPNERKLNFWERLYLPAVVQGLAYTWRKMRSPRYTFQYPDELWYPPDSYRGRPVLVEENGRPRCVACGLCARACPPLAISMQAKEVDDVKEREPAWFEINMLRCIYCGYCEEVCPEEAIVMSKEYDLTFQSRDEAIFGLEKLLVPAERLKDRLEWLDRYKDPQYGQHWEFRKENNLHSLKDRPFLKWLLEEEGMEELKSTHLRPEEPVAAERSWGGVRAEG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY972099
EMBL· GenBank· DDBJ
AAY42993.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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