Q4QFL6 · Q4QFL6_LEIMA

  • Protein
    Poly(A) polymerase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions. Also active with manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

170050100150200250300350400450500550600650700
TypeIDPosition(s)Description
Binding site99ATP (UniProtKB | ChEBI)
Binding site103Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site103Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site103-105ATP (UniProtKB | ChEBI)
Binding site105Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site105Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site157ATP (UniProtKB | ChEBI)
Binding site157Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site215ATP (UniProtKB | ChEBI)
Binding site224ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpoly(A) RNA polymerase activity
Molecular FunctionRNA binding
Biological ProcessmRNA processing
Biological ProcessRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Poly(A) polymerase
  • EC number

Gene names

    • ORF names
      LMJF_14_1180

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MHOM/IL/81/Friedlin
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    Q4QFL6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain41-201Poly(A) polymerase nucleotidyltransferase
Domain206-346Poly(A) polymerase central
Domain375-562Poly(A) polymerase RNA-binding
Region452-488Disordered
Compositional bias464-488Polar residues
Region570-700Disordered
Compositional bias601-624Polar residues

Sequence similarities

Belongs to the poly(A) polymerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    700
  • Mass (Da)
    76,513
  • Last updated
    2005-07-19 v1
  • MD5 Checksum
    095B8D88D857000F0643A4AE9F962028
MTSTTVTDKDFLAKKIVSADGPKGGEVVHELSLSEWCITRIEPEEESNRRRSVLERIVNVVRVWIRHTMITEFRMPEAAAAQVEGRIFATGSYRYNVHTSGSDIDMVLIAPSRITREHFFNTLAPRLKSEPWVTDLHCIRESRVPIIAMVCDGIDIDLSFGSIRQDRVPEVITDDLLQGLDEQSVLSCNAVRVAHNIMDLVPNKAVFRQTLRFVKAWGKARSIYSNTFGFPSGIGWAILTAFVCQCYPNQNAAGMVTRFFRTYHTWFKPNPHETGTENRAIYLTESMRARTHLGRGWDPRESKSDAMALFPVLTPAVPYGNTCYNVTLTNLRQLCDEFQRGHDLLSKDLGMSAAEAKAKFGPFGVWSRVLEPAPFFGKFQHYLQIKVSCSDAEHYQAYADGVESRIRILWAGNASSRGHTLEDYRQLRLHLNPRRFEDPEEVQLRTRLTSKATGAAAAASHTRGSVGSRASGQLGDGGSSLHGNLNVKDSSAPSGPTWFTAHYFIGMTVDTKVSSAKIDLAPAIRTFHTVVRELRQYREGVTRLPAITVVDMARIPTFVKEAAGYIEETAAAQEERSSSEAEEARNNSSTAARADAAKRDGTSAASTTTSKPSTAASAADGSASETSRGLHDGGAGNGAASSIDSYARKRTRDQYGTDGHGTVAAKAETSTAAGSGSGAAGRAQAEEDADDIEQALGLDF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias464-488Polar residues
Compositional bias601-624Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR796410
EMBL· GenBank· DDBJ
CAJ03188.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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