Q4Q9W0 · SLX1_LEIMA
- ProteinStructure-specific endonuclease subunit SLX1 homolog
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids704 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | Slx1-Slx4 complex | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | crossover junction DNA endonuclease activity | |
Molecular Function | metal ion binding | |
Biological Process | double-strand break repair via homologous recombination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameStructure-specific endonuclease subunit SLX1 homolog
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionQ4Q9W0
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000383764 | 1-704 | Structure-specific endonuclease subunit SLX1 homolog | |||
Sequence: MDTRFHCVYLLTSLDPQCEGDFYIGYSVNPLRRLRQHNGELVNGARRTGRRGRPWTIVCCVSGFPDDRTALKFEWCWQHPTASARLRHTIDILTGLRRLPYAVATLHLLVRASLFCQLDLTLHIFESAFLQEAAARAEVFLARRRGAFAVGGGLQAESPRVGTQQHSQRSSSLQGQADGVVTPPLPALDSQGELQGASTAAALATTTAASHLLPPLTPSLLLHVENTTREAFEDAYLSHDRCLLLPSAGMGVVVGEAGKEDSHMSASAGTSCPYDVSLLSQAARAEWSNASFASDSDDEDTRRLAPYCPSAGSSTPSPQRVRTAASPALLGYRSEERAGDGVWEASPGSSVGCGAALRSFSSPPPPRESSPRSASRPPVCTGINASASLAVDAPHGDVTAACPSSPAAAPAPQPRIPLRFADYGEVDFARAHAEEQHRLHHGLLPCSLCALPLQPSCLVYCSRAPFCTLRCHLSCLAMWMLYAEAEAAATIDGTDKSPALLSHAPPAPISPLRRLIPSQPCPCPLCGVLLHWGSLVKELKKRVVVERRLHAVQRRIRMEQRWQARLAHIEPTKRSTGAAMRRRQRARVGAAAALAKGAGKVPGAASTVPAPTMHAGPARRDAPRVSSPISFGEPTLTSFAAAASCPSPSASLAALSPTSASPISRHNGHSNTVTATHTAAAAAAASDASLLSLTDFCEEDWLLP |
Interaction
Subunit
Forms a heterodimer with a member of the SLX4 family.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-90 | GIY-YIG | ||||
Sequence: RFHCVYLLTSLDPQCEGDFYIGYSVNPLRRLRQHNGELVNGARRTGRRGRPWTIVCCVSGFPDDRTALKFEWCWQHPTASARLRHTI | ||||||
Region | 157-180 | Disordered | ||||
Sequence: ESPRVGTQQHSQRSSSLQGQADGV | ||||||
Compositional bias | 158-178 | Polar residues | ||||
Sequence: SPRVGTQQHSQRSSSLQGQAD | ||||||
Region | 290-323 | Disordered | ||||
Sequence: ASFASDSDDEDTRRLAPYCPSAGSSTPSPQRVRT | ||||||
Compositional bias | 308-322 | Polar residues | ||||
Sequence: CPSAGSSTPSPQRVR | ||||||
Region | 354-378 | Disordered | ||||
Sequence: GAALRSFSSPPPPRESSPRSASRPP | ||||||
Zinc finger | 446-526 | SLX1-type | ||||
Sequence: CSLCALPLQPSCLVYCSRAPFCTLRCHLSCLAMWMLYAEAEAAATIDGTDKSPALLSHAPPAPISPLRRLIPSQPCPCPLC | ||||||
Region | 601-629 | Disordered | ||||
Sequence: VPGAASTVPAPTMHAGPARRDAPRVSSPI | ||||||
Region | 650-671 | Disordered | ||||
Sequence: ASLAALSPTSASPISRHNGHSN |
Sequence similarities
Belongs to the SLX1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length704
- Mass (Da)74,798
- Last updated2005-07-19 v1
- Checksum55E47B08853FE55E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 158-178 | Polar residues | ||||
Sequence: SPRVGTQQHSQRSSSLQGQAD | ||||||
Compositional bias | 308-322 | Polar residues | ||||
Sequence: CPSAGSSTPSPQRVR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FR796421 EMBL· GenBank· DDBJ | CAJ05240.1 EMBL· GenBank· DDBJ | Genomic DNA |