Q4Q7A6 · Q4Q7A6_LEIMA
- ProteinAdenylate kinase isoenzyme 6 homolog
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids180 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Catalytic activity
- AMP + ATP = 2 ADP
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 16 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 16 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 18 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 19 | ADP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 19 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 20 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 20 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 20 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 21 | ADP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 21 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 24 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 35 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 66 | Mn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 78 | Mn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 79 | Mn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 82 | Mn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 86 | Mn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 94 | Mn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 117 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 121 | Mn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 143 | Mn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 154 | ADP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 156 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | nuclear lumen | |
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | metal ion binding | |
Molecular Function | RNA binding | |
Molecular Function | rRNA primary transcript binding | |
Biological Process | cellular response to starvation | |
Biological Process | maturation of SSU-rRNA | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase isoenzyme 6 homolog
- EC number
- Short namesAK6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionQ4Q7A6
Proteomes
Organism-specific databases
Interaction
Subunit
Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 116-126 | LID | ||||
Sequence: KRQYSEAKRAE | ||||||
Coiled coil | 150-177 | |||||
Sequence: LVRENDTLEQMAATVEEIRERVEVLKVE |
Sequence similarities
Belongs to the adenylate kinase family. AK6 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length180
- Mass (Da)20,934
- Last updated2005-07-19 v1
- Checksum8FEE0A348E1B1661
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FR796426 EMBL· GenBank· DDBJ | CAJ06352.1 EMBL· GenBank· DDBJ | Genomic DNA |