Q4Q7A6 · Q4Q7A6_LEIMA

  • Protein
    Adenylate kinase isoenzyme 6 homolog
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site16ADP (UniProtKB | ChEBI)
Binding site16ATP (UniProtKB | ChEBI)
Binding site18ADP (UniProtKB | ChEBI)
Binding site18ATP (UniProtKB | ChEBI)
Binding site19ADP (UniProtKB | ChEBI)
Binding site19ATP (UniProtKB | ChEBI)
Binding site20ADP (UniProtKB | ChEBI)
Binding site20ATP (UniProtKB | ChEBI)
Binding site20Mn2+ 1 (UniProtKB | ChEBI)
Binding site21ADP (UniProtKB | ChEBI)
Binding site21ATP (UniProtKB | ChEBI)
Binding site24Mn2+ 2 (UniProtKB | ChEBI)
Binding site35Mn2+ 2 (UniProtKB | ChEBI)
Binding site66Mn2+ 3 (UniProtKB | ChEBI)
Binding site78Mn2+ 4 (UniProtKB | ChEBI)
Binding site79Mn2+ 4 (UniProtKB | ChEBI)
Binding site82Mn2+ 4 (UniProtKB | ChEBI)
Binding site86Mn2+ 5 (UniProtKB | ChEBI)
Binding site94Mn2+ 6 (UniProtKB | ChEBI)
Binding site117ATP (UniProtKB | ChEBI)
Binding site121Mn2+ 7 (UniProtKB | ChEBI)
Binding site143Mn2+ 6 (UniProtKB | ChEBI)
Binding site154ADP (UniProtKB | ChEBI)
Binding site156ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentcytoplasmic stress granule
Cellular Componentnuclear lumen
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Molecular FunctionrRNA primary transcript binding
Biological Processcellular response to starvation
Biological Processmaturation of SSU-rRNA
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6 homolog
  • EC number
  • Short names
    AK6
  • Alternative names
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • ORF names
      LMJF_30_1890

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MHOM/IL/81/Friedlin
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    Q4Q7A6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, coiled coil.

TypeIDPosition(s)Description
Region116-126LID
Coiled coil150-177

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    180
  • Mass (Da)
    20,934
  • Last updated
    2005-07-19 v1
  • Checksum
    8FEE0A348E1B1661
MEQPKGINILITGTPGTGKTSMAEMIAAELDGFQHLEVGKLVKENHFYTEYDTELDTHIIEEKDEDRLLDFMEPIMVSRGNHVVDYHSSELFPERWFHMVVVLHTSTEVLFERLTKRQYSEAKRAENMEAEIQCICEEEARDAYEDDIVLVRENDTLEQMAATVEEIRERVEVLKVERGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR796426
EMBL· GenBank· DDBJ
CAJ06352.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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