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Q4PE27 · PFA4_USTMA

Function

function

Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.

Catalytic activity

Features

Showing features for active site.

148150100150200250300350400450
TypeIDPosition(s)Description
Active site211S-palmitoyl cysteine intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi apparatus
Molecular Functionprotein-cysteine S-palmitoyltransferase activity
Biological Processprotein palmitoylation
Biological Processprotein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Palmitoyltransferase PFA4
  • EC number
  • Alternative names
    • Protein S-acyltransferase
      (PAT
      )
    • Protein fatty acyltransferase 4

Gene names

    • Name
      PFA4
    • ORF names
      UMAG_11136

Organism names

Accessions

  • Primary accession
    Q4PE27
  • Secondary accessions
    • A0A0D1E7T6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-66Cytoplasmic
Transmembrane67-87Helical
Topological domain88-108Lumenal
Transmembrane109-129Helical
Topological domain130-223Cytoplasmic
Transmembrane224-244Helical
Topological domain245-265Lumenal
Transmembrane266-286Helical
Topological domain287-481Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002129701-481Palmitoyltransferase PFA4

Keywords

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-22Disordered
Domain181-231DHHC
Region370-481Disordered
Compositional bias385-430Polar residues

Domain

The DHHC domain is required for palmitoyltransferase activity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    54,443
  • Last updated
    2015-09-16 v2
  • MD5 Checksum
    A8E49B1876AF67CF4622FEDE079D015D
MTNQDPDDGAYPSSQSDDDGIEALAINRQSRPLLAYEDQAAGQSDAFTDRDIPASTAPLTGRRRTPLSWTEVIWVSLTLLLIAVLGYSSQLYVMLPYYEKTPSFSPQALAAVLVPFNLGLLAIYYNYWLCVTTDAGSVPAGWQPEWSALEPVASLAELEHLHLVAEEEPSLELKQAIYRPRYCKTCSAFKPPRSHHCKTCQRCVLRMDHHCPWLANCVGHFNHAHFIRFLFYVDVTCLYHLIMISCRVLDSFNSYTYWREPCARELVWLVVNYALCIPVILLVGIFSLYHFYCLAVNQTTIESWEKDRTATMIRRGRVRKVKYPYDLGLWRNVRQVLGASPLVWCLPGAGARMAGDGLKYPVANGLDSGSQYRWPPKDPSRPHPSRRTWASSSSPFTYPERSNPILDPTLSTRFPHNSSPSSSDSHSSLHLPHPPSLLDPLPHHFDPPHDPDTQPVNCPKRVSVRRGSEGYEVRPHTPWSV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias385-430Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM003142
EMBL· GenBank· DDBJ
KIS70460.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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