Q4P804 · CSN5_USTMA

Function

function

Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.

Features

Showing features for binding site.

140650100150200250300350400
TypeIDPosition(s)Description
Binding site146Zn2+ (UniProtKB | ChEBI); catalytic
Binding site148Zn2+ (UniProtKB | ChEBI); catalytic
Binding site159Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCOP9 signalosome
Cellular Componentcytoplasm
Molecular FunctiondeNEDDylase activity
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Biological Processprotein deneddylation
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    COP9 signalosome complex subunit 5
  • EC number

Gene names

    • Name
      RRI1
    • Synonyms
      CSN5
    • ORF names
      UMAG_03759

Organism names

Accessions

  • Primary accession
    Q4P804
  • Secondary accessions
    • A0A0D1DV81

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001948571-406COP9 signalosome complex subunit 5

Interaction

Subunit

Component of the COP9 signalosome (CSN) complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif, region.

TypeIDPosition(s)Description
Domain61-200MPN
Motif146-159JAMM motif
Region320-341Disordered

Domain

The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

Sequence similarities

Belongs to the peptidase M67A family. CSN5 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    44,129
  • Last updated
    2005-07-19 v1
  • Checksum
    1D659A052E1EE811
MTAPSSSSSASMARANFELNNAIIPLSSTTLDSIFAYDNEAQRAILHAQPWKTDPHFFQKVRISAVALIKMVMHARSGGIYEIMGLMQGKIDVENRTLYVMDSFALPVEGTETRVNAQNEAYEYMVQYLDHSKEVGRLENVVGWYHSHPGYGCWLSGIDVNTQRTNQQFQDPFVAIVIDPNRTISSGKVDIGAFRTFPEGYTSSSSIGGGDSEYQSIPLSKIEDFGVHANEYYPLEVEHFKSSLDGKLLDLLWNKYWQNTLSQSPLVSNRAYTTSQIRDLADKLAQTNAAVLNRNSVSSAPFTTTAGAASVRIGAGKDVAAETEQNSGGSAKDTPAGTAQDAAGLVKEFEQRSKMSAISRASNDAAKLASEANHGLLASQLKHTLFHNHTATPTPASASAPTPIRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM003149
EMBL· GenBank· DDBJ
KIS68179.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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