Q4LE74 · Q4LE74_HUMAN
- ProteinMYO9B variant protein
- GeneMYO9B variant protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2028 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | myosin complex | |
Molecular Function | actin binding | |
Molecular Function | ATP binding | |
Molecular Function | GTPase activator activity | |
Molecular Function | metal ion binding | |
Molecular Function | microfilament motor activity | |
Biological Process | actin filament-based movement | |
Biological Process | regulation of small GTPase mediated signal transduction | |
Biological Process | Rho protein signal transduction |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4LE74
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-120 | Ras-associating | ||||
Sequence: AAYHLHIYPQLSTTESQASCRVTATKDSTTSDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLLWPRRAQDEHPQEDGYYFLLQERNA | ||||||
Domain | 152-959 | Myosin motor | ||||
Sequence: ADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVSYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPEDYFYLNQHNLKIEDGEDLKHDFERLKQAMEMVGFLPATKKQIFAVLSAILYLGNVTYKKRATGREEGLEVGPPEVLDTLSQLLKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQHEDNKYFLGTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLDSKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLH | ||||||
Region | 715-740 | Disordered | ||||
Sequence: AEKAAGMSSPGAQSHPEELPRGASTP | ||||||
Region | 841-863 | Actin-binding | ||||
Sequence: LNKLLEALGKAEPFFIRCIRSNA | ||||||
Region | 1052-1304 | Disordered | ||||
Sequence: QMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDSRVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQ | ||||||
Compositional bias | 1054-1072 | Basic and acidic residues | ||||
Sequence: ISEKQKAEEKEREALEAAR | ||||||
Compositional bias | 1144-1185 | Basic and acidic residues | ||||
Sequence: HEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPS | ||||||
Compositional bias | 1193-1211 | Basic and acidic residues | ||||
Sequence: GVSLLEDKKESREDETLLV | ||||||
Compositional bias | 1213-1230 | Polar residues | ||||
Sequence: ETEAENTSQKQPTEQPQA | ||||||
Region | 1326-1416 | Disordered | ||||
Sequence: AAASPSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDAGLSPGSQV | ||||||
Compositional bias | 1353-1370 | Polar residues | ||||
Sequence: PTEERRTSFSTSDVSKLL | ||||||
Region | 1461-1490 | Disordered | ||||
Sequence: GLEAPSGQQHRHAAGEKRTKEPGGKGKKNR | ||||||
Compositional bias | 1470-1490 | Basic and acidic residues | ||||
Sequence: HRHAAGEKRTKEPGGKGKKNR | ||||||
Domain | 1638-1687 | Phorbol-ester/DAG-type | ||||
Sequence: GHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHC | ||||||
Domain | 1709-1894 | Rho-GAP | ||||
Sequence: DSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKY | ||||||
Compositional bias | 1984-2003 | Basic and acidic residues | ||||
Sequence: EDITYRLPELDPRGSDEENL | ||||||
Region | 1984-2028 | Disordered | ||||
Sequence: EDITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGQY |
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,028
- Mass (Da)229,714
- Last updated2005-08-02 v1
- Checksum36290F3E28DD0469
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Compositional bias | 1054-1072 | Basic and acidic residues | ||||
Sequence: ISEKQKAEEKEREALEAAR | ||||||
Compositional bias | 1144-1185 | Basic and acidic residues | ||||
Sequence: HEKVPSSREKRESRRQRGLEHVKFQNKHIQSCKEESALREPS | ||||||
Compositional bias | 1193-1211 | Basic and acidic residues | ||||
Sequence: GVSLLEDKKESREDETLLV | ||||||
Compositional bias | 1213-1230 | Polar residues | ||||
Sequence: ETEAENTSQKQPTEQPQA | ||||||
Compositional bias | 1353-1370 | Polar residues | ||||
Sequence: PTEERRTSFSTSDVSKLL | ||||||
Compositional bias | 1470-1490 | Basic and acidic residues | ||||
Sequence: HRHAAGEKRTKEPGGKGKKNR | ||||||
Compositional bias | 1984-2003 | Basic and acidic residues | ||||
Sequence: EDITYRLPELDPRGSDEENL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB209997 EMBL· GenBank· DDBJ | BAE06079.1 EMBL· GenBank· DDBJ | mRNA |