Q4LBB9 · OCTB2_DROME

Function

function

Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359).
Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988).
During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988).
Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionG protein-coupled amine receptor activity
Molecular Functionoctopamine receptor activity
Biological Processadenylate cyclase-activating adrenergic receptor signaling pathway
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processfertilization
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processovulation
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of synaptic assembly at neuromuscular junction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Octopamine receptor beta-2R
  • Short names
    DmOct-beta-12; DmOct-beta-2R

Gene names

    • Name
      Octbeta2R
    • Synonyms
      Octbeta2
    • ORF names
      CG33976

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q4LBB9
  • Secondary accessions
    • B7FNM5
    • Q9VG53
    • Q9VG54

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-157Extracellular
Transmembrane158-178Helical; Name=1
Topological domain179-190Cytoplasmic
Transmembrane191-211Helical; Name=2
Topological domain212-233Extracellular
Transmembrane234-256Helical; Name=3
Topological domain257-270Cytoplasmic
Transmembrane271-291Helical; Name=4
Topological domain292-320Extracellular
Transmembrane321-341Helical; Name=5
Topological domain342-412Cytoplasmic
Transmembrane413-433Helical; Name=6
Topological domain434-444Extracellular
Transmembrane445-465Helical; Name=7
Topological domain466-536Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Males appear viable and fertile whereas females are sterile (PubMed:25099506, PubMed:25353988).
Female pre- and post-mating behaviors, such as courtship and post-mating rejection, are not affected and sperm storage appears normal (PubMed:25099506, PubMed:25353988).
However, ovulation and egg-laying is severely impaired and females display a strong delay in copulation rates (PubMed:25099506, PubMed:25353988).
Ovaries are enlarged due to a higher number of retained eggs and the small number of eggs that are laid are not fertilized (PubMed:25353988).
Larvae fail to respond to starvation by increasing locomotor activity (PubMed:21186359).
Reduced growth of octopaminergic and glutamatergic (type I and type II) neuromuscular junctions (PubMed:21186359).
Decrease in the number of terminal type I and type II boutons and in the motile filopodia-like extensions (synaptopods) which form during the expansion of type II terminals in developing larvae (PubMed:21186359).

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00000699601-536Octopamine receptor beta-2R
Glycosylation18N-linked (GlcNAc...) asparagine
Glycosylation92N-linked (GlcNAc...) asparagine
Glycosylation113N-linked (GlcNAc...) asparagine
Glycosylation126N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the adult, expressed in the superior protocerebrum and the optic lobe medulla of the central nervous system, nurse cells of egg chambers in the ovary at oogenic stages 1-10, and spermatogonia and spermatocytes in the testis (PubMed:22303848).
Expressed in the oviduct epithelium (PubMed:25099506).
Also expressed in the spermatheca (PubMed:25353988).
Expressed in embryonic and larval ventral nerve cord and brain lobe, embryonic and larval salivary glands and larval imaginal disk and midgut (PubMed:22303848).
Also expressed in larval synaptic boutons (PubMed:21186359).

Developmental stage

Expressed in adult, pupae and third instar larvae. Levels peak at the late embryonic and late larvae stages. Relatively low expression in the pupal stage, with a slight increase in the adult.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-26Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    536
  • Mass (Da)
    60,379
  • Last updated
    2005-10-11 v2
  • Checksum
    67599A6DAC41280F
MLLCDGLGPEPPRQRHRNRTSAARIRKRPKCCCGDGGSGNQAEQPGGIVSNPISYGQSLTTLARVTAAALTTAAMLHTTNALAATGSSSASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQMVDNL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E1JIJ4E1JIJ4_DROMEOctbeta2R630
A0A126GUT9A0A126GUT9_DROMEOctbeta2R536

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict121in Ref. 1; CAI56430
Sequence conflict124in Ref. 1; CAI56430
Sequence conflict439in Ref. 1; CAI56430

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ880689
EMBL· GenBank· DDBJ
CAI56430.1
EMBL· GenBank· DDBJ
mRNA
BT053715
EMBL· GenBank· DDBJ
ACK77633.1
EMBL· GenBank· DDBJ
mRNA
AE014297
EMBL· GenBank· DDBJ
AAF54835.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AFH06394.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AFH06395.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AFH06396.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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