Q4KMQ2 · ANO6_HUMAN
- ProteinAnoctamin-6
- GeneANO6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids910 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes
Miscellaneous
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)This reaction proceeds in the forward direction.
- a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)This reaction proceeds in the backward direction.
Activity regulation
Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity).
Features
Showing features for binding site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAnoctamin-6
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4KMQ2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-300 | Cytoplasmic | ||||
Sequence: MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA | ||||||
Transmembrane | 301-321 | Helical | ||||
Sequence: WLGYYTQMLLLAAVVGVACFL | ||||||
Topological domain | 322-375 | Extracellular | ||||
Sequence: YGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS | ||||||
Transmembrane | 376-396 | Helical | ||||
Sequence: FGTLVFAVFMGVWVTLFLEFW | ||||||
Topological domain | 397-455 | Cytoplasmic | ||||
Sequence: KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLC | ||||||
Transmembrane | 456-476 | Helical | ||||
Sequence: ASAVFFWILLIIASVIGIIVY | ||||||
Topological domain | 477-509 | Extracellular | ||||
Sequence: RLSVFIVFSAKLPKNINGTDPIQKYLTPQTATS | ||||||
Transmembrane | 510-530 | Helical | ||||
Sequence: ITASIISFIIIMILNTIYEKV | ||||||
Topological domain | 531-551 | Cytoplasmic | ||||
Sequence: AIMITNFELPRTQTDYENSLT | ||||||
Transmembrane | 552-572 | Helical | ||||
Sequence: MKMFLFQFVNYYSSCFYIAFF | ||||||
Topological domain | 573-601 | Extracellular | ||||
Sequence: KGKFVGYPGDPVYWLGKYRNEECDPGGCL | ||||||
Transmembrane | 602-621 | Helical | ||||
Sequence: LELTTQLTIIMGGKAIWNNI | ||||||
Topological domain | 622-663 | Cytoplasmic | ||||
Sequence: QEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL | ||||||
Transmembrane | 664-684 | Helical | ||||
Sequence: FYEYLEMIIQFGFVTLFVASF | ||||||
Transmembrane | 685-705 | Helical | ||||
Sequence: PLAPLLALVNNILEIRVDAWK | ||||||
Topological domain | 706-722 | Cytoplasmic | ||||
Sequence: LTTQFRRLVPEKAQDIG | ||||||
Transmembrane | 723-743 | Helical | ||||
Sequence: AWQPIMQGIAILAVVTNAMII | ||||||
Topological domain | 744-836 | Extracellular | ||||
Sequence: AFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA | ||||||
Transmembrane | 837-857 | Helical | ||||
Sequence: FIIVMEHVIYSVKFFISYAIP | ||||||
Topological domain | 858-910 | Cytoplasmic | ||||
Sequence: DVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Scott syndrome (SCTS)
- Note
- DescriptionA mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents.
- See alsoMIM:262890
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_028109 | 128 | in dbSNP:rs2162321 | |||
Sequence: A → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,104 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), glycosylation, disulfide bond.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000191757 | 1-910 | UniProt | Anoctamin-6 | |||
Sequence: MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE | |||||||
Modified residue (large scale data) | 156 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 160 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 169 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 238 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 256 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 329 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 330↔371 | UniProt | |||||
Sequence: CTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLC | |||||||
Disulfide bond | 337↔364 | UniProt | |||||
Sequence: CHPDIGGKIIMCPQCDRLCPFWKLNITC | |||||||
Disulfide bond | 348↔806 | UniProt | |||||
Sequence: CPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTC | |||||||
Disulfide bond | 351↔355 | UniProt | |||||
Sequence: CDRLC | |||||||
Glycosylation | 361 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 493 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 595↔600 | UniProt | |||||
Sequence: CDPGGC | |||||||
Glycosylation | 777 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 790 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 802 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 909 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Induction
Gene expression databases
Organism-specific databases
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q4KMQ2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length910
- Mass (Da)106,165
- Last updated2006-10-17 v2
- Checksum8F7F1CB78FAAEB78
Q4KMQ2-2
- Name2
- Differences from canonical
- 23-23: I → IGDVPASRRPFLTPHTHLPSSL
Q4KMQ2-3
- Name3
- Differences from canonical
- 1-23: MKKMSRNVLLQMEEEEDDDDGDI → MFCAA
Q4KMQ2-4
- Name4
- Differences from canonical
- 843-910: HVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE → YLALLPRLGHSGMILAHCNLRLPVDCCMCYRFVDEIRLLEQLTSDFIDSLYYIFSISIISIFFSVTFFFLLLSLGPTPCFSVSNFLS
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8VX71 | F8VX71_HUMAN | ANO6 | 45 | ||
A0A7P0T8Y2 | A0A7P0T8Y2_HUMAN | ANO6 | 729 | ||
A0A7P0TAW4 | A0A7P0TAW4_HUMAN | ANO6 | 694 | ||
A0A7P0TBC5 | A0A7P0TBC5_HUMAN | ANO6 | 899 | ||
A0A7P0TBD5 | A0A7P0TBD5_HUMAN | ANO6 | 715 | ||
A0A7P0TBI1 | A0A7P0TBI1_HUMAN | ANO6 | 771 | ||
A0A7P0TAF4 | A0A7P0TAF4_HUMAN | ANO6 | 854 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_046819 | 1-23 | in isoform 3 | |||
Sequence: MKKMSRNVLLQMEEEEDDDDGDI → MFCAA | ||||||
Alternative sequence | VSP_042893 | 23 | in isoform 2 | |||
Sequence: I → IGDVPASRRPFLTPHTHLPSSL | ||||||
Sequence conflict | 837 | in Ref. 2; AAH98410 | ||||
Sequence: F → L | ||||||
Alternative sequence | VSP_046820 | 843-910 | in isoform 4 | |||
Sequence: HVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE → YLALLPRLGHSGMILAHCNLRLPVDCCMCYRFVDEIRLLEQLTSDFIDSLYYIFSISIISIFFSVTFFFLLLSLGPTPCFSVSNFLS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC009248 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC009778 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC063924 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC098410 EMBL· GenBank· DDBJ | AAH98410.1 EMBL· GenBank· DDBJ | mRNA | ||
BC136445 EMBL· GenBank· DDBJ | AAI36446.1 EMBL· GenBank· DDBJ | mRNA | ||
AL833405 EMBL· GenBank· DDBJ | CAD38638.1 EMBL· GenBank· DDBJ | mRNA |