Q4JBG1 · Q4JBG1_SULAC
- ProteinCoenzyme A biosynthesis bifunctional protein CoaBC
- GenecoaBC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids409 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalytic activity
- (R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H+ + N-[(R)-4-phosphopantothenoyl]-L-cysteine
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FMN per subunit.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphopantothenate--cysteine ligase activity | |
Molecular Function | phosphopantothenoylcysteine decarboxylase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | pantothenate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoenzyme A biosynthesis bifunctional protein CoaBC
- Alternative names
Including 2 domains:
- Recommended namePhosphopantothenoylcysteine decarboxylase
- EC number
- Short namesPPC decarboxylase ; PPC-DC
- Alternative names
- Recommended namePhosphopantothenate--cysteine ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus
Accessions
- Primary accessionQ4JBG1
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-195 | Phosphopantothenoylcysteine decarboxylase | ||||
Sequence: MVHPSKKIIGEVSRELLNKKILVGVTASVSIYKSLDLVRALMRRGANVRVIMSKDSIRLINPMMFHWATGEEPVVSVGGEIEHVELAEEYDALVIAPSTANTISKLANGIADTSITLTALNFVGIKKPVILVPAMHLTMYEAPQFKENIEKLVKQGIEIISPEITRDVAHYPDIEYLSSYITSFLLRGKDLKGYK | ||||||
Domain | 19-157 | Flavoprotein | ||||
Sequence: KKILVGVTASVSIYKSLDLVRALMRRGANVRVIMSKDSIRLINPMMFHWATGEEPVVSVGGEIEHVELAEEYDALVIAPSTANTISKLANGIADTSITLTALNFVGIKKPVILVPAMHLTMYEAPQFKENIEKLVKQGI | ||||||
Domain | 191-377 | DNA/pantothenate metabolism flavoprotein C-terminal | ||||
Sequence: LKGYKIVVTAGPTREYIDPVRFISNSSSGTMGVSIANEAYFRGADVILVHGPLSSSVKPYTKRIRVDTTQEMAENVEKLVRDEKYGIVILAGAPADFKPKNTASSKIDSHSEVPKVELETTPKISSKLSIYRPLLVGFSAETVNSDEELIEKAKMKKERHKFDIIVANNVKRKDIGFSSEYNEVIVI | ||||||
Region | 196-409 | Phosphopantothenate--cysteine ligase | ||||
Sequence: IVVTAGPTREYIDPVRFISNSSSGTMGVSIANEAYFRGADVILVHGPLSSSVKPYTKRIRVDTTQEMAENVEKLVRDEKYGIVILAGAPADFKPKNTASSKIDSHSEVPKVELETTPKISSKLSIYRPLLVGFSAETVNSDEELIEKAKMKKERHKFDIIVANNVKRKDIGFSSEYNEVIVIGNSFVRKLEKNYKTIIARELLDIVKYEVSRKV |
Sequence similarities
In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length409
- Mass (Da)45,552
- Last updated2005-08-02 v1
- ChecksumE22624F282D48029
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000077 EMBL· GenBank· DDBJ | AAY79868.1 EMBL· GenBank· DDBJ | Genomic DNA |