Q4J9K6 · FLAX_SULAC
- ProteinArchaeal flagellar motor scaffold protein FlaX
- GeneflaX
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids250 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the archaellum (PubMed:22081969, PubMed:23129770, PubMed:24103130, PubMed:26508112).
FlaX, FlaH and FlaI form the core cytoplasmic motor complex of the crenarchaeal archaellum (PubMed:24103130, PubMed:26508112).
FlaX forms a ring that may act as a membrane-bound cytoplasmic scaffold that guides the assembly of the archaellum motor complex (PubMed:24103130).
Is essential for archaellum assembly (PubMed:23129770).
FlaX, FlaH and FlaI form the core cytoplasmic motor complex of the crenarchaeal archaellum (PubMed:24103130, PubMed:26508112).
FlaX forms a ring that may act as a membrane-bound cytoplasmic scaffold that guides the assembly of the archaellum motor complex (PubMed:24103130).
Is essential for archaellum assembly (PubMed:23129770).
Activity regulation
The presence of the flagellar core components FlaH, FlaI and FlaJ seems to be crucial for the stability of FlaX.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | archaeal-type flagellum | |
Cellular Component | plasma membrane |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameArchaeal flagellar motor scaffold protein FlaX
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus
Accessions
- Primary accessionQ4J9K6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-9 | Extracellular | ||||
Sequence: MAIQDLLQS | ||||||
Transmembrane | 10-30 | Helical | ||||
Sequence: SLFIILIGVGIPIAAFLEILF | ||||||
Topological domain | 31-250 | Cytoplasmic | ||||
Sequence: RVILPKTKRVQTQQSPQNISQEQRFPTQQKPANDETSKYSSDSIEKALKDVLGKMDKKENELLTNITNSFNEMKKLIENLNSAVEELALSVKASESDSSSPFNTIIQQEEEHVSREISTVSQLVGSNNPNNVNLTWFIKSCVLLEIMEYDEEKIKQLYELGYVSSDDMFTILRILSFIKNRKITAKELASIAANIAESYSSLTPEIKKYIMILEGGGVNG |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
The deletion mutant lacks flagella and is non-motile.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460732 | 1-250 | Archaeal flagellar motor scaffold protein FlaX | |||
Sequence: MAIQDLLQSSLFIILIGVGIPIAAFLEILFRVILPKTKRVQTQQSPQNISQEQRFPTQQKPANDETSKYSSDSIEKALKDVLGKMDKKENELLTNITNSFNEMKKLIENLNSAVEELALSVKASESDSSSPFNTIIQQEEEHVSREISTVSQLVGSNNPNNVNLTWFIKSCVLLEIMEYDEEKIKQLYELGYVSSDDMFTILRILSFIKNRKITAKELASIAANIAESYSSLTPEIKKYIMILEGGGVNG |
Interaction
Subunit
The S.acidocaldarius archaellum assembly machinery and its filament consist of seven proteins (FlaB, FlaF, FlaG, FlaH, FlaI, FlaJ and FlaX) (PubMed:22081969).
FlaX assembles into ring-shaped oligomers (PubMed:23129770).
Interacts directly with FlaH and the motor ATPase FlaI (PubMed:23129770, PubMed:24103130, PubMed:26508112, PubMed:29605923).
FlaX assembles into ring-shaped oligomers (PubMed:23129770).
Interacts directly with FlaH and the motor ATPase FlaI (PubMed:23129770, PubMed:24103130, PubMed:26508112, PubMed:29605923).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q4J9K6 | Saci_1173 Q4J9L0 | 5 | EBI-8759763, EBI-8759747 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 42-68 | Polar residues | ||||
Sequence: TQQSPQNISQEQRFPTQQKPANDETSK | ||||||
Region | 42-72 | Disordered | ||||
Sequence: TQQSPQNISQEQRFPTQQKPANDETSKYSSD |
Domain
The C terminal region is involved in the oligomerization, but is also essential for interaction with FlaH and FlaI.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length250
- Mass (Da)28,056
- Last updated2005-08-02 v1
- ChecksumD5FBFCA640DF8E89
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 42-68 | Polar residues | ||||
Sequence: TQQSPQNISQEQRFPTQQKPANDETSK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000077 EMBL· GenBank· DDBJ | AAY80524.1 EMBL· GenBank· DDBJ | Genomic DNA |