Q4IMJ1 · ADE_GIBZE
- ProteinAdenine deaminase
- GeneAAH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids353 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Catalytic activity
- adenine + H+ + H2O = hypoxanthine + NH4+
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 19 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 21 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 208 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 211 | Proton donor | ||||
Sequence: E | ||||||
Site | 232 | Important for catalytic activity | ||||
Sequence: H | ||||||
Binding site | 289 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 290 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | adenine deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | adenine catabolic process | |
Biological Process | hypoxanthine salvage | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenine deaminase
- EC number
- Short namesADE
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium
Accessions
- Primary accessionQ4IMJ1
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000256235 | 1-353 | Adenine deaminase | |||
Sequence: MCKSRVHSFLQALPKVEQHLHIEGTLEPELLFTLAEKNGIELPNDPVYESADKLRERYGRFTSLDDFLHYYYLGMSVLITENDFETLAYQYFQRAAGENVRHAEIFFDPQAHIARGVSYDTVVAGLVAAKHRAQKELGITVELIVCILRHLPVPESHALVDTLLDRGHFNDGTLTGFGMVSSEKAFPPELFTDVYARVAKTGTHLTTHAGEEAPPSFITASLEHLKVSRIDHGLAAAQDPELLKKLAANRTLLTFCPWSNVALCNLPELADAPVREFLDAGVLFSVNSDDPAYFGAYVQEVYCRVQDTFNLSVKDWAWIVRGAVEESWCSEERKKEILKEMEQVLEKYKDLDA |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)39,774
- Last updated2005-08-16 v1
- Checksum6F9DE1537E7814F5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS231663 EMBL· GenBank· DDBJ | ESU06894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HG970332 EMBL· GenBank· DDBJ | CEF73714.1 EMBL· GenBank· DDBJ | Genomic DNA |