Q4IMJ1 · ADE_GIBZE

Function

function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

135350100150200250300350
TypeIDPosition(s)Description
Binding site19Zn2+ (UniProtKB | ChEBI); catalytic
Binding site21Zn2+ (UniProtKB | ChEBI); catalytic
Binding site208Zn2+ (UniProtKB | ChEBI); catalytic
Active site211Proton donor
Site232Important for catalytic activity
Binding site289Zn2+ (UniProtKB | ChEBI); catalytic
Binding site290substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionadenine deaminase activity
Molecular Functionzinc ion binding
Biological Processadenine catabolic process
Biological Processhypoxanthine salvage
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine deaminase
  • EC number
  • Short names
    ADE
  • Alternative names
    • Adenine aminohydrolase
      (AAH
      )

Gene names

    • Name
      AAH1
    • ORF names
      FGRRES_01567, FGSG_01567

Organism names

Accessions

  • Primary accession
    Q4IMJ1
  • Secondary accessions
    • A0A0E0RR39
    • V6QY46

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002562351-353Adenine deaminase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    39,774
  • Last updated
    2005-08-16 v1
  • Checksum
    6F9DE1537E7814F5
MCKSRVHSFLQALPKVEQHLHIEGTLEPELLFTLAEKNGIELPNDPVYESADKLRERYGRFTSLDDFLHYYYLGMSVLITENDFETLAYQYFQRAAGENVRHAEIFFDPQAHIARGVSYDTVVAGLVAAKHRAQKELGITVELIVCILRHLPVPESHALVDTLLDRGHFNDGTLTGFGMVSSEKAFPPELFTDVYARVAKTGTHLTTHAGEEAPPSFITASLEHLKVSRIDHGLAAAQDPELLKKLAANRTLLTFCPWSNVALCNLPELADAPVREFLDAGVLFSVNSDDPAYFGAYVQEVYCRVQDTFNLSVKDWAWIVRGAVEESWCSEERKKEILKEMEQVLEKYKDLDA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231663
EMBL· GenBank· DDBJ
ESU06894.1
EMBL· GenBank· DDBJ
Genomic DNA
HG970332
EMBL· GenBank· DDBJ
CEF73714.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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