Q4I5U9 · BUR1_GIBZE

Function

function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site43-51ATP (UniProtKB | ChEBI)
Binding site66ATP (UniProtKB | ChEBI)
Active site169Proton acceptor

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functioncyclin-dependent protein serine/threonine kinase activity
Molecular Functionprotein serine kinase activity
Molecular FunctionRNA polymerase II CTD heptapeptide repeat kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      BUR1
    • ORF names
      FGRRES_16828, FGSG_07409

Organism names

Accessions

  • Primary accession
    Q4I5U9
  • Secondary accessions
    • A0A0E0SBS4
    • I1RTA8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000856831-539Serine/threonine-protein kinase BUR1

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-27Disordered
Domain37-339Protein kinase
Region370-539Disordered
Compositional bias471-539Basic and acidic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    539
  • Mass (Da)
    61,614
  • Last updated
    2012-10-31 v2
  • Checksum
    1320870273F2BD61
MEKLSETTPNGTSPRTFALNHSRPRSSFKGCSRISDYELLGKLGEGTFGEVHRARLRKTGALVALKKIIMHHEKDGFPITALREIKLLKLLSHKNILRLEDMAIEHPTRQTDKRKKPIVYMATPYMDHDLSGLLDNPSVQFKEPQIKCYMLQLLEGLRYLHDSRILHRDMKAANLLINNKGILQIADFGLARHYDGRTPESGVPMGEGKRDYTGLVVTRWYRPPELLLQLRQYTPAIDVWGVGCVFGEMLYGKPILAGESDAAQLDIIWDLMGSPNEENMPRWKSLPGADHLTPRPRTGNLETRFRQYGSGAVSLLKELLRLDWRTRINAVDALQHPWFKMQPLPLEPHEIPTYEESHELDRRKFHDRKAALPPAPKGGTVGVGPDANGATAGFNSNEPYGNGRNGVNGGRYRNGPDDRRPAWQRERGAGLPPRPPPNNDDADFRERGPPRARGPPGPRGPDVDTYIPAYNRDDPGRRRDDRPPPPRDDRPPPRDDRRRRNSREDRRFDRDRGTMSRSRSPRHDRSRDRDRPDHNGYRR

Sequence caution

The sequence ESU13671.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias471-539Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231666
EMBL· GenBank· DDBJ
ESU13671.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
HG970335
EMBL· GenBank· DDBJ
CEF83887.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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