Q4GVU8 · Q4GVU8_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ4GVU8
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGVLGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSLLLLLASAMVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AVLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFIHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFTIMFIGVNLTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNILSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-511 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRTELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYM |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,071
- Last updated2005-08-30 v1
- Checksum766088D9F783F77C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU482342 EMBL· GenBank· DDBJ | ACA22373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383204 EMBL· GenBank· DDBJ | ACM69780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM107337 EMBL· GenBank· DDBJ | ADG46466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ704496 EMBL· GenBank· DDBJ | AFF96408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX987459 EMBL· GenBank· DDBJ | AGA55911.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX900416 EMBL· GenBank· DDBJ | AGC16424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185800 EMBL· GenBank· DDBJ | AID12811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ185801 EMBL· GenBank· DDBJ | AID12824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ676782 EMBL· GenBank· DDBJ | AID61001.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ676784 EMBL· GenBank· DDBJ | AID61027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT819233 EMBL· GenBank· DDBJ | ALM03578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU867580 EMBL· GenBank· DDBJ | AOT80857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU867608 EMBL· GenBank· DDBJ | AOT81221.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF695952 EMBL· GenBank· DDBJ | AUT78487.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008266 EMBL· GenBank· DDBJ | BAE07443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008387 EMBL· GenBank· DDBJ | BAE09016.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008695 EMBL· GenBank· DDBJ | BAE13022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009443 EMBL· GenBank· DDBJ | BAG39021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013148 EMBL· GenBank· DDBJ | BAN79832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP013289 EMBL· GenBank· DDBJ | BAN81524.1 EMBL· GenBank· DDBJ | Genomic DNA |