Q4GVU8 · Q4GVU8_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      COX1
      , coxI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • HNsq0219
    • PDsq0056
    • TCsq0007
    • Mdmd25
    • Chuk101
    • GL37
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q4GVU8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,071
  • Last updated
    2005-08-30 v1
  • Checksum
    766088D9F783F77C
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRTELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU482342
EMBL· GenBank· DDBJ
ACA22373.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383204
EMBL· GenBank· DDBJ
ACM69780.1
EMBL· GenBank· DDBJ
Genomic DNA
HM107337
EMBL· GenBank· DDBJ
ADG46466.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ704496
EMBL· GenBank· DDBJ
AFF96408.1
EMBL· GenBank· DDBJ
Genomic DNA
JX987459
EMBL· GenBank· DDBJ
AGA55911.1
EMBL· GenBank· DDBJ
Genomic DNA
JX900416
EMBL· GenBank· DDBJ
AGC16424.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185800
EMBL· GenBank· DDBJ
AID12811.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ185801
EMBL· GenBank· DDBJ
AID12824.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ676782
EMBL· GenBank· DDBJ
AID61001.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ676784
EMBL· GenBank· DDBJ
AID61027.1
EMBL· GenBank· DDBJ
Genomic DNA
KT819233
EMBL· GenBank· DDBJ
ALM03578.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867580
EMBL· GenBank· DDBJ
AOT80857.1
EMBL· GenBank· DDBJ
Genomic DNA
KU867608
EMBL· GenBank· DDBJ
AOT81221.1
EMBL· GenBank· DDBJ
Genomic DNA
MF695952
EMBL· GenBank· DDBJ
AUT78487.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008266
EMBL· GenBank· DDBJ
BAE07443.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008387
EMBL· GenBank· DDBJ
BAE09016.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008695
EMBL· GenBank· DDBJ
BAE13022.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009443
EMBL· GenBank· DDBJ
BAG39021.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013148
EMBL· GenBank· DDBJ
BAN79832.1
EMBL· GenBank· DDBJ
Genomic DNA
AP013289
EMBL· GenBank· DDBJ
BAN81524.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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